Purpose: The treatment of giant incisional hernia (IH) with loss of domain (LOD, IHLD) is considerably challenging due to technical difficulties and subsequent post-operative complications. These post-operative risks may be anticipated by calculating the abdominal cavity (AC) volume (ACV) and the IH volume (IHV) on the preoperative CT-scans, using the AC and IH dimensions (Tanaka's method) or using tridimensional volumetry (Sabbagh's method). These techniques are often time-consuming and require specific softwares. The aim of the present study was to develop a simple method to rapidly obtain the LOD-ratio on the preoperative CT-Scan.
Methods: The CT-scans (n = 89) of patients with IHLD were retrospectively studied. Several ratios were calculated using different parameters of the AC and the IH, including width, height and depth, the areas (axial and sagittal ellipse, as well as freehand sagittal surface areas) and these were compared with the reference methods of Sabbagh et al. and Tanaka et al. RESULTS: The LOD ratios calculated from the two reference methods gave similar results (ICC = 0.82, p < 0.0001). The new "R-ratios" (Reims-ratios) obtained from the IH and AC surface areas measured using the "freehand ROI" tool on sagittal view or roughly evaluated by an ellipse on axial view showed excellent correlation with both reference ratios (all ICC ≥ 0.71, p < 0.0001).
Conclusion: The LOD ratio may be quickly obtained by drawing two circles on the pre-operative CT scan ("R ratios") and available on the webpage https://romeo.univ-reims.fr/Rratio/ . This will certainly help surgeons to routinely anticipate the post-operative complications before IHLD repair.
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http://dx.doi.org/10.1007/s10029-021-02474-w | DOI Listing |
Ann Bot
January 2025
Laboratório de Ecologia e Biogeografia de Plantas, Departamento de Biodiversidade, Setor Palotina, Universidade Federal do Paraná, Rua Pioneiro, 2153, Jardim Dallas, CEP 85950 000, Palotina, Paraná, Brazil.
Background: Epiphyllous bryophytes are a group of plants with complex adaptations to colonize the leaves of vascular plants and are considered one of the most specialized and sensitive groups to environmental changes. Despite their specificity and ecological importance, these plants represent a largely neglected group in relation to scientific research and ecological data. This lack of information directly affects our understanding of biodiversity patterns and compromises the conservation of this group in threatened ecosystems.
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Ziekenhuis Groep Twente, Almelo, Netherlands.
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Cell Death Dis
January 2025
In vitro Toxicology and Biomedicine, Dept. inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457, Konstanz, Germany.
Neurite degeneration (ND) precedes cell death in many neurodegenerative diseases. However, it remains unclear how this compartmentalized cell death process is orchestrated in the central nervous system (CNS). The establishment of a CNS axotomy model (using modified 3D LUHMES cultures) allowed us to study metabolic control of ND in human midbrain-derived neurons without the use of toxicants or other direct disturbance of cellular metabolism.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Physics, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan.
Bending loss is one of the serious problems for constructing nanophotonic integrated circuits. Recently, many works reported that valley photonic crystals (VPhCs) enable significantly high transmission via 120-degree sharp bends. However, it is unclear whether the high bend-transmission results directly from the valley-photonic effects, which are based on the breaking of inversion symmetry.
View Article and Find Full Text PDFPLoS Genet
January 2025
Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St. SW, Rochester, Minnesota 55905, United States of America.
Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and progressive bulbar palsy, involve loss of muscle control resulting from death of motor neurons. Although the exact pathogenesis of these syndromes remains elusive, many are caused by genetically inherited mutations. Thus, it is valuable to identify additional genes that can impact motor neuron survival and function.
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