Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41374-021-00588-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correction to: DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.
Lab Invest
October 2021
Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Middle Yanchang Road, Shanghai, 200072, PR China.
Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes.
J Diabetes Complications
October 2012
Department of Ophthalmology, Flinders Medical Centre and Flinders University, South Australia, Australia.
Asymmetric dimethylarginine (ADMA) levels are elevated in diabetes and likely contribute to diabetic complications such as retinopathy and nephropathy. The DDAH enzymes are primarily responsible for ADMA metabolism. Polymorphisms in the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes have been previously associated with serum ADMA levels in type 2 diabetes (T2DM).
View Article and Find Full Text PDFHaplotypic association of DDAH1 with susceptibility to pre-eclampsia.
Mol Hum Reprod
January 2005
Department of Obstetrics and Gynaecology, Kuopio University Hospital, University of Kuopio, Kuopio, Finland.
Association between pre-eclampsia (PEE1) and the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes, which play a role in the regulation of nitric oxide synthesis and release, was studied. In a case-control study design single nucleotide polymorphisms (SNPs) were determined at eight sites in the DDAH1 gene and at one site (Pro231Pro) in the DDAH2 gene from 132 women with pre-eclampsia and 112 healthy controls. Three SNPs in the DDAH1 gene were associated with pre-eclampsia, showing complete linkage disequilibrium with each other, but none of the associations in the allele or genotype data reached statistical significance in either of the genes after the correction for multiple testing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!