In the case of single fetal demise in a twin gestation, the fate of the dead twin, surviving twin, and mother depend on the exact time of fetal demise. The dead twin may "vanish" in a first trimester death; form a mummified "fetus papyraceus" due to mechanical compression in the second trimester or show changes of maceration in the third trimester. Hematological complications in the mother and neurological complications in the surviving twin may ensue in later trimester deaths. We report a unique case of an undiagnosed fetus papyraceus incidentally detected in an otherwise normal placenta. Identification of such cases is essential due to the occurrence of severe complications in some of the cases, medicolegal implications for the caregivers, and to improve the understanding of embryological development and fetal demise in twin or multiple gestations.
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http://dx.doi.org/10.4103/IJPM.IJPM_307_20 | DOI Listing |
BMC Pregnancy Childbirth
January 2025
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Utah Health, 30 N. Mario Capecchi Dr., Level 5 South, Salt Lake City, UT, 84132, USA.
Background: Fetal growth restriction (FGR) is a leading risk factor for stillbirth, yet the diagnosis of FGR confers considerable prognostic uncertainty, as most infants with FGR do not experience any morbidity. Our objective was to use data from a large, deeply phenotyped observational obstetric cohort to develop a probabilistic graphical model (PGM), a type of "explainable artificial intelligence (AI)", as a potential framework to better understand how interrelated variables contribute to perinatal morbidity risk in FGR.
Methods: Using data from 9,558 pregnancies delivered at ≥ 20 weeks with available outcome data, we derived and validated a PGM using randomly selected sub-cohorts of 80% (n = 7645) and 20% (n = 1,912), respectively, to discriminate cases of FGR resulting in composite perinatal morbidity from those that did not.
Obstet Gynecol Clin North Am
March 2025
Center for Fetal Medicine and Women's Ultrasound, Los Angeles, CA 90048, USA; Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:
Several parents globally face stillbirth, which takes a toll on their mental health and well-being. We would like to discuss the differences between grief and mental health and ways care must be tailored toward the specific needs of the bereaved. Recent research shows that there is a sense of personal responsibility that accompanies stillbirth and pregnancy loss.
View Article and Find Full Text PDFJ Matern Fetal Neonatal Med
December 2025
Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, Poland.
Introduction: Small-for-gestational age (SGA) newborns are at increased risk of adverse neonatal outcomes and the risk is related to the etiology of growth restriction: highest in placental insufficiency, lowest in constitutional SGA. The aim of this study was to investigate if placental growth factor (PlGF), soluble fms-like tyrosine kinase-1(sFlt-1) or sFlt-1/PlGF ratio are efficient in prediction of adverse neonatal outcomes in SGA newborns delivered ≥34 weeks of gestation.
Methods: A prospective observational multicenter cohort study was performed.
Eur J Pediatr
January 2025
Institute of Clinical Medicine and Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.
Unlabelled: Twin pregnancies are associated with higher risks of adverse maternal and neonatal outcomes compared to singleton pregnancies. This retrospective nationwide cohort study analyzed trends in twin pregnancy outcomes in Finland from 2008 to 2023 using data from the Finnish Medical Birth Register. Outcomes assessed included perinatal mortality, stillbirths, neonatal mortality, neonatal intensive care unit (NICU) admissions, and hospitalization rates at one week of age.
View Article and Find Full Text PDFBMJ Glob Health
January 2025
Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
Study Objective: Stillbirth is burdensome in low-income and middle-income countries (LMICs), especially in sub-Saharan Africa and South Asia. Currently, there are two core outcome sets (COS) for stillbirth (prevention and bereavement care), but these were developed with limited reflection of the needs of parents in an LMIC setting. To address this gap, the objective of this study was to establish consensus on the most important outcomes for stillbirth prevention and bereavement care following stillbirth in sub-Saharan Africa and South Asia.
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