[Cholestatic toxic-vascular encephalopathy and encephalomyelopathy].

Patients with mechanical jaundice showed signs of organic lesions of the nervous system: the syndrome of cholestatic encephalopathy (n = 56) and encephalomyelopathy (n = 9). Pathomorphological disorders are presented in the form of toxico-hypoxic changes of the neural cells and neuroglia in combination with organic changes in the vascular wall and functional disturbances of the blood flow and the cerebrospinal fluid dynamics. It is suggested that marked autointoxication and hemodynamic disturbances play the leading role in the pathogenesis of neurological disorders in mechanical jaundice.