The Transition-Edge Sensor (TES) is an extremely sensitive device, which is used to measure the energy of individual x-ray photons. For astronomical spectrometry applications, SRON develops a frequency domain multiplexing readout system for kilopixel arrays of such TESs. Each TES is voltage biased at a specific frequency in the range of 1-5 MHz. Isolation between the individual pixels is obtained through very narrow-band (high-Q) lithographic LC resonators. To prevent energy resolution degradation due to intermodulation line noise, the bias frequencies are distributed on a regular grid. The requirements on the accuracy of the LC resonance frequency are very high. The deviation of the resonance frequencies due to production tolerances is significant with respect to the bandwidth, and a controller is necessary to compensate for the LC series impedance. We present two such controllers: a simple orthogonal proportional-integral controller and a more complex impedance estimator. Both controllers operate in baseband and try to make the TES current in-phase with the bias voltage, effectively operating as phase-locked loops. They allow off-LC-resonance operation of the TES pixels while preserving the TES thermal response and energy resolution. Extensive experimental results-published in a companion paper recently-with the proposed methods show that these controllers allow the preservation of single pixel energy resolution in multiplexed operation.
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Nat Mater
January 2025
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Cells use 'active' energy-consuming motor and filament protein networks to control micrometre-scale transport and fluid flows. Biological active materials could be used in dynamically programmable devices that achieve spatial and temporal resolution that exceeds current microfluidic technologies. However, reconstituted motor-microtubule systems generate chaotic flows and cannot be directly harnessed for engineering applications.
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From Department of Neuroradiology (Niklas Lützen, Charlotte Zander, Horst Urbach), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany and Department of Neurosurgery (Jürgen Beck, Florian Volz, Katharina Wolf, Amir El Rahal), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Type 2 CSF leaks are spinal lateral dural tears, causing spontaneous intracranial hypotension (SIH). They may be visualized with digital subtraction myelography (DSM), cone-beam CT (CBCT) myelography, energy-integrating detector or photon-counting CT myelography. A recently introduced ultrahigh-resolution cone-beam CT (UHR-CBCT) myelography has shown beneficial visualization of CSF-venous fistula, another cause of SIH.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Molecular Genetics, Institute of Biology, Faculty of Life Sciences, Humboldt Universität zu Berlin, Berlin 10115, Germany.
The chloroplast genome encodes key components of the photosynthetic light reaction machinery as well as the large subunit of the enzyme central for carbon fixation, Ribulose-1,5-bisphosphat-carboxylase/-oxygenase (RuBisCo). Its expression is predominantly regulated posttranscriptionally, with nuclear-encoded RNA-binding proteins (RBPs) playing a key role. Mutants of chloroplast gene expression factors often exhibit impaired chloroplast biogenesis, especially in cold conditions.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
University of Crete, Department of Physics, Heraklion 70013, Greece.
It was recently demonstrated that a multitude of realizations of several magnetic sensing technologies satisfy the energy resolution limit, which connects a quantity composed by the variance of the magnetic field estimate, the sensor volume and the measurement time, and having units of action, with ℏ. A first-principles derivation of this limit is still elusive. We here present such a derivation based on quantum thermodynamic arguments.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA.
Classical transport of electrons and holes in nanoscale devices leads to heating that severely limits performance, reliability, and efficiency. In contrast, recent theory suggests that interband quantum tunneling and subsequent thermalization of carriers with the lattice results in local cooling of devices. However, internal cooling in nanoscale devices is largely unexplored.
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