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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis.
J Biomed Sci
January 2025
Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Background: Recent studies indicate that N6-methyladenosine (mA) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation.
Methods: Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) was used to detect changes in mA levels in cells. Transmission electron microscopy and flow cytometry were used to detect mitochondrial reactive oxygen species (ROS).
β-Catenin/c-Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations.
Adv Biol (Weinh)
January 2025
Laboratory of Clinical Proteomic, "V Fazzi" Hospital, Lecce, 73100, Italy.
Ammonia a by-product of nitrogen containing molecules is detoxified by liver into non-toxic urea and glutamine. Impaired ammonia detoxification leads to hyperammonemia. Ammonia has a dual role on autophagy, it acts as inducer at low concentrations and as inhibitor at high concentrations.
View Article and Find Full Text PDFCycling Dof Factor 3 mediates light-dependent ascorbate biosynthesis by activating GDP-L-galactose phosphorylase in Rosa roxburghii fruit.
Plant Physiol
January 2025
Guizhou Engineering Research Center for Fruit Crops, Agricultural College, Guizhou University, Guiyang, Guizhou, China.
Light plays an important role in determining the L-ascorbate (AsA) pool size in plants, primarily through the transcriptional regulation of AsA metabolism-related genes. However, the specific mechanism of transcriptional induction responsible for light-dependent AsA biosynthesis remains unclear. In this study, we used a promoter sequence containing light-responsive motifs from GDP-L-galactose phosphorylase 2 (RrGGP2), a key gene involved in AsA overproduction in Rosa roxburghii fruits, to identify participating transcription factors.
View Article and Find Full Text PDFIntegrating Bacteriocins and Biofilm-Degrading Enzymes to Eliminate Persistence.
Int J Mol Sci
January 2025
Characterization and Interventions for Foodborne Pathogens, Agricultural Research Service, United States Department of Agriculture, Wyndmoor, PA 19038, USA.
is a Gram-positive bacterium causing listeriosis, a severe infection responsible for significant morbidity and mortality globally. Its persistence on food processing surfaces via biofilm formation presents a major challenge, as conventional sanitizers and antimicrobials exhibit limited efficacy against biofilm-embedded cells. This study investigates a novel approach combining an engineered polysaccharide-degrading enzyme (CAase) with a bacteriocin (thermophilin 110) produced by .
View Article and Find Full Text PDFEfficacy of SC5 Fermentation Filtrate in Inhibiting the Growth and Development in Sunflower.
Int J Mol Sci
December 2024
Institute of Animal Husbandry, Pasture and Green Agriculture, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China.
is a destructive pathogen responsible for sunflower sclerotinia rot, resulting in substantial yield and economic losses worldwide. species have demonstrated the capacity to inhibit plant pathogen growth through the production of secondary metabolites. However, there are fewer recent studies focusing on the application of metabolites in inhibiting growth and development and controlling sunflower sclerotinia rot disease.
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