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Catechin-Based Polyphenol Nanoparticles Ameliorated Ferroptosis to Alleviate Brain Injury after Intracerebral Hemorrhage.
ACS Appl Mater Interfaces
January 2025
Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang 550000, China.
Spontaneous intracerebral hemorrhagic stroke (ICH) is a highly aggressive disease, with a high incidence and mortality rate. Iron deposition following ICH leads to oxidative damage and motor dysfunction, significantly impacting the overall quality of life for those affected. Here, a polyphenolic nanomedicine, catechin-based polyphenol nanoparticles surface-modified by thiol-terminated poly(ethylene glycol) (CNPs@PEG), was developed through the oxidative polymerization and self-assembly of catechin, a natural compound in tea.
View Article and Find Full Text PDFTetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway.
Front Pharmacol
November 2024
Bone and Joint Surgery, Qingdao Municipal Hospital, Qingdao, China.
Article Synopsis
- - Tetramethylpyrazine (TMP) is a natural compound that shows promise for protecting nerve cells by potentially preventing a type of cell death called ferroptosis, particularly after spinal cord injuries.
- - Experiments demonstrated that TMP improves motor functions in rats with spinal cord injuries and protects against nerve cell death and tissue damage by regulating iron metabolism through the NRF2/ARE pathway.
- - The study found that TMP enhances the activity of NRF2, which helps manage iron levels and reduce oxidative stress, ultimately contributing to the neuroprotective effects against ferroptosis and supporting recovery after injury.
Exercise progressions and regressions in sports training and rehabilitation.
J Bodyw Mov Ther
October 2024
Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
Background: The field of sports training and rehabilitation is constantly evolving, seeking excellence in performance and optimal restoration of injured athletes. In this dynamic context, exercise progressions and regressions are fundamental, preventing injuries and adapting training to individual capacity, ensuring appropriate challenge and avoiding harmful overloads.
Objective: To describe the essence of exercise progressions and regressions, exploring in detail the intrinsic subtleties to these, as well as their relevance in the field of sports training and rehabilitation.
High correlation of quantitative susceptibility mapping and echo intensity measurements of nigral iron overload in Parkinson's disease.
J Neural Transm (Vienna)
November 2024
Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.
Article Synopsis
- This study examined the connection between two imaging techniques, Quantitative Susceptibility Mapping (QSM) and Transcranial Sonography (TCS), to evaluate iron levels in the substantia nigra of patients with Parkinson's disease (PD).
- Eighteen imaging sessions were conducted on 15 PD patients, revealing strong correlations between nigral iron susceptibility and TCS measurements of echogenicity.
- The findings suggest that increased iron accumulation in the substantia nigra may contribute to the observed echogenicity in PD, with echogenicity likely reflecting stored ferritin-bound iron in microglia.
Caspase-2 is a condensate-mediated deubiquitinase in protein quality control.
Nat Cell Biol
November 2024
State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Article Synopsis
- Protein ubiquitination is crucial for managing protein quality during cellular stress, but its excessive accumulation can lead to neurodegenerative diseases.
- Researchers identified caspase-2 (CASP2) as a deubiquitinase that helps remove excess ubiquitin chains from misfolded proteins in a newly discovered structure called ubstressome.
- The absence of CASP2 in mice results in the build-up of poly-ubiquitinated proteins, demonstrating its important role in maintaining cellular ubiquitin balance and revealing new functions of protein condensates in quality control.
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