AI Article Synopsis
- Syrian hamsters can develop a deadly illness similar to human hantavirus pulmonary syndrome (HPS) when infected with Andes virus (ANDV), while Hantaan virus (HTNV) leads to an asymptomatic infection.
- Researchers used NanoString technology to study 770 genes in the blood of these hamsters, revealing significant differences in immune response genes related to type I interferon, complement activation, and apoptosis pathways between the two virus infections.
- The study found that ANDV delays the immune response, which may help the virus evade the host's defenses and worsen the disease; this research is the first of its kind and could lead to new treatment options for hantavirus infections.
Article Abstract
Background: Syrian hamsters infected with Andes virus (ANDV) develop a disease that recapitulates many of the salient features of human hantavirus pulmonary syndrome (HPS), including lethality. Infection of hamsters with Hantaan virus (HTNV) results in an asymptomatic, disseminated infection. In order to explore this dichotomy, we examined the transcriptome of ANDV- and HTNV-infected hamsters.
Results: Using NanoString technology, we examined kinetic transcriptional responses in whole blood collected from ANDV- and HTNV-infected hamsters. Of the 770 genes analyzed, key differences were noted in the kinetics of type I interferon sensing and signaling responses, complement activation, and apoptosis pathways between ANDV- and HTNV-infected hamsters.
Conclusions: Delayed activation of type I interferon responses in ANDV-infected hamsters represents a potential mechanism that ANDV uses to subvert host immune responses and enhance disease. This is the first genome-wide analysis of hantavirus-infected hamsters and provides insight into potential avenues for therapeutics to hantavirus disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360559 | PMC |
| http://dx.doi.org/10.1371/journal.pntd.0009592 | DOI Listing |
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