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Patent landscape of small molecule inhibitors of METTL3 (2020-present).
Expert Opin Ther Pat
December 2024
Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Introduction: Methyltransferase-like protein 3 (METTL3), in complex with METTL14, is the key 'writer' protein for RNA mA methylation, accounting for almost all mRNA mA modifications. Recent studies reveal that METTL3 is implicated in the development and progression of various types of cancers. Targeting METTL3 with small molecule inhibitors represents a promising therapeutic strategy for cancer.
View Article and Find Full Text PDFLessons Learned: Preventing Faculty Burnout.
J Physician Assist Educ
December 2024
Chelsey Hoffmann, PA-C, MS, RD, Division of Pain Medicine, Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Introduction: Physician Assistant/Associate (PA) clinicians face a major learning curve when transitioning from patient provider to PA educator. Furthermore, PA educators juggle multiple responsibilities including teaching, grading, advising, mentoring, interviewing, researching, writing, and more. Recently published research has indicated that 52.
View Article and Find Full Text PDFExtremely elevated erythrocyte sedimentation rates: Associations with patients' diagnoses and clinical characteristics.
Rom J Intern Med
December 2024
Department of Internal Medicine Goztepe Training and Research Hospital, Istanbul Medeniyet University, Kadikoy/Istanbul, Türkiye.
Introduction: The aim of the study was to assess the etiological distribution of patients with an erythrocyte sedimentation rate (ESR) over 100 mm/hour and to evaluate differences in demographic, comorbidity, laboratory characteristics, and clinical outcomes.
Methods: This retrospective observational clinical study included patients aged 18 years and older who were admitted to the internal medicine inpatient clinic between May 1, 2015 and June 1, 2021 and had ESR values above 100 mm/h. Demographic data, comorbidities, laboratory parameters, imaging studies, histopathological findings, microbiological and serological data, along with in-hospital and post-discharge mortality, were collected from the hospital's electronic database.
Predictors of survival and functioning of arteriovenous fistula in patients on hemodialysis during a one-year follow-up.
Rom J Intern Med
December 2024
Academy of Educational and Medical Vocational Studies, Department of Bridges, headquarters Kruševac, Serbia.
Introduction: The mortality rate of hemodialysis patients is extremely high and it is significantly affected by vascular access dysfunction. Our research aimed to determine predictive parameters of arteriovenous fistula functioning and survival in a one-year follow-up period.
Methods: The research was organized as a prospective, one-year study, which included 120 dialysis patients who were followed for one year.
A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint.
Adv Sci (Weinh)
December 2024
Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, China.
Aneuploidy eggs are a common cause of human infertility, spontaneous abortion, or trisomy syndromes. The spindle assembly checkpoint (SAC) plays a crucial role in preventing aneuploidy in oocytes, yet it is unclear if additional mechanisms exist to ensure oocyte adherence to this checkpoint. It is now revealed that the microtubule-associated protein NUSAP can prevent oocytes from evading the SAC and regulate the speed of the cell cycle.
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