AI Article Synopsis
- - Mismatch repair protein deficiency is found in 0.8-2% of pancreatic ductal adenocarcinomas and can make these tumors more responsive to immunotherapy.
- - A patient with Lynch syndrome and this type of pancreatic cancer had a strong response to pembrolizumab but suffered from immune-related diabetic ketoacidosis, leading to treatment stoppage.
- - Despite halting treatment, the patient has remained in remission for 3 years, prompting speculation that the severe side effect might have been linked to his exceptional response to therapy.
Article Abstract
Mismatch repair protein deficiency occurs in 0.8-2% of pancreatic ductal adenocarcinomas and confers susceptibility to immunotherapy. Herein, we report the case of a patient with Lynch syndrome-associated, locally advanced mismatch repair protein deficiency pancreatic ductal adenocarcinomas who demonstrated a sustained response to second-line treatment with pembrolizumab, but eventually developed immune-related diabetic ketoacidosis requiring discontinuation of treatment. He has since remained in remission, off treatment, over the following 3 years, with regular surveillance showing no clinical or radiographic evidence of disease progression. The patient's unusual disease course raises the question of whether this serious immune-related adverse event affecting the organ of malignant involvement may have predicted his remarkable and durable response.
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| http://dx.doi.org/10.2217/imt-2021-0008 | DOI Listing |
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