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| http://dx.doi.org/10.14814/phy2.14966 | DOI Listing |
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Measurement of urine calcium, magnesium and phosphate: Preanalytical considerations in the elimination of the acidification step.
Clin Chim Acta
January 2025
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA, United States. Electronic address:
Background: Traditionally, urine analysis of calcium (Ca), magnesium (Mg) and phosphate (Phos) requires acidification of the sample. This study aims to assess the need for acidification and evaluate preanalytical factors that influence the accurate measurement of these analytes in urine.
Results: A total of 107 spot urine samples from patients with a median age of 9 years (95% ≤ 21 years of age, range 5 days to 46 years) were analyzed for Ca (n = 94), Mg (n = 97), and Phos (n = 102) with and without acidification.
Effect of Ficus Carica and Zea Mays on Calcium Release from Oxalocalcic Urinary Calculi Using the Potentiometric Method.
Curr Pharm Biotechnol
December 2024
LMAE, Faculty of Sciences Exactes, University of Mascara, B.P. 763, Mascara, Algeria.
Introduction: A stone is a compact mass of one or more crystallised substances. The essential mechanism of stone formation is an excessive concentration of poorly soluble compounds in the urine. In excessive concentration, these compounds precipitate into crystals, which then aggregate to form a stone.
View Article and Find Full Text PDFEmpagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial.
Nat Med
January 2025
Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Article Synopsis
- A study investigated the effectiveness of empagliflozin, a sodium-glucose cotransporter 2 inhibitor, in preventing kidney stones in nondiabetic adults with a history of calcium or uric acid stones.
- The trial involved 53 participants who were given either empagliflozin or a placebo in a crossover design, focusing on changes in urine supersaturation ratios relevant to stone recurrence.
- Results showed significant reductions in urine supersaturation ratios for calcium phosphate in calcium stone formers and uric acid in uric acid stone formers, indicating that empagliflozin may help prevent certain types of kidney stones without serious side effects.
Deciphering the mineral code of urinary stones: A first look at zinc isotopes.
Environ Pollut
December 2024
Nu Instruments, Wrexham Industrial Estate, 74 Clywedog Road South, Wrexham, LL13 9XS, United Kingdom.
Zinc (Zn) is an essential element for all living organisms, and Zn isotopes play a key role in studying the formation of disease. Despite extensive studies on Zn isotopes in healthy and diseased human tissues, the role of Zn isotopes in urinary stones remains unexplored. This study investigates Zn isotopes in 37 urinary stones using multi-collector inductively coupled plasma mass spectrometry.
View Article and Find Full Text PDFNon-contrast CT attenuation value of renal papilla is a novel predictor of recurrence in kidney stone disease.
BMC Urol
December 2024
Department of Urology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, 641-0012, Japan.
In calcium stone formers, most stones grow attached to Randall's plaque, which can be identified by measuring the computed tomography (CT) attenuation value of renal papilla. We hypothesized that the CT attenuation value of renal papilla can predict the severity (recurrent or multiple stone former) and recurrence of the stone disease. We retrospectively reviewed the charts of 180 calcium oxalate stone formers who underwent non-contrast CT and 24-hour urine chemistry in our hospital between September 2012 and November 2021.
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