Sequence-controlled polymers are an emerging class of synthetic polymers with a regulated sequence of monomers. In the past decade, tremendous progress has been made in the synthesis of polymers with the sophisticated sequence control approaching the level manifested in biopolymers. In contrast, the exploration of novel functions that can be achieved by controlling synthetic polymer sequences represents an emerging focus in polymer science. This Viewpoint will survey recent advances in the functional applications of sequence-controlled polymers and provide a perspective on the challenges and outlook for pursuing future applications of this fascinating class of macromolecules.
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http://dx.doi.org/10.1021/acsmacrolett.0c00855 | DOI Listing |
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January 2025
Shanghai Key Laboratory of Advanced Polymeric Materials, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Endowing biomimetic sequence-controlled polymers with chiral functionality to construct stimuli-responsive chiral materials offers a promising approach for innovative chiroptical switch, but it remains challenging. Herein, it is reported that the self-assembly of sequence-defined chiral amphiphilic alternating azopeptoids to generate photo-responsive and ultrathin bilayer peptoidosomes with a vesicular thickness of ≈1.50 nm and a diameter of around ≈290 nm.
View Article and Find Full Text PDFMacromol Biosci
January 2025
Cluster for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, UNSW, Sydney, NSW, 2052, Australia.
Invasive fungal infections cause over 3.7 million deaths worldwide annually, underscoring the critical need for new antifungal agents. Developing selective antifungal agents is challenging due to the shared eukaryotic nature of both fungal and mammalian cells.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Macromol Rapid Commun
November 2024
CNRS, UMR 7006, ISIS, 8 allée Gaspard Monge, Université de Strasbourg, Strasbourg, 67000, France.
A photo-assisted process is explored for improving the synthesis of oligo(triazole amide)s, which are prepared by solid phase synthesis using a repeated cycle of two reactions: amine-carboxylic acid coupling and copper-catalyzed azide-alkyne cycloaddition (CuAAC). The improvement of the second reaction is investigated herein. A catalytic system involving Cu(II)Cl, N,N,N',N″,N″-pentamethyldiethylenetriamine (PMDETA) and a titanocene photoinitiator is explored for reducing the reaction time of CuAAC.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Copolymerization stands as a versatile and potent method for tailoring polymer properties by adjusting structural unit composition and sequence distribution. However, achieving sequence-controlled copolymerization in a one-step and one-pot process remains challenging. This study introduces a solvent-dependent sequence-controlled copolymerization strategy to produce block and statistical copolyesters from 4-phenyl-2-oxabicyclo[2.
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