The aims of this study are to investigate the effect of acrylamide on the level of proinflammatory cytokines in the blood of acrylamide-treated rats and to find the modulatory impact of probiotics on those cytokines. Thirty-two rats were divided into four groups: rats which received 20 mg acrylamide, acrylamide with 20 mg probiotics, acrylamide with 200 mg probiotics, and standard water and food (groups 1-4, respectively). The serum levels of cytokines were measured on days 0, 15, and 30. Group 1 showed an increased serum level of IL-1, IL-6, and TNF- after 15 days, and they decreased in day 30. Serum IL-6 level was significantly decreased on days 15 and 30 in rats in group 2 compared to the controls. TNF- and IL-1 levels were not statistically different after treated with probiotics. The exposure of rats to acrylamide led to increased systemic inflammation as evidenced by higher levels of proinflammatory cytokines, and probiotics can modulate this inflammation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318771 | PMC |
| http://dx.doi.org/10.1155/2021/2268770 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Betaine on Blood Parameters Related to the Iron Status in Acrylamide-Treated Rats.
Arch Razi Inst
June 2022
Department of Physiology, College of Medicine, University of Anbar, Ramadi, Iraq.
It has been well documented that acrylamide (ACR) is a human carcinogen. One of the consequences of ACR exposure is central and peripheral nervous system damage, which may lead to hallucinations, drowsiness, and numbness in the hands, as well as legs. Betaine (BET) plays an active role in methylation reactions, including DNA methylation, the integrity of cell membranes, and memory development.
View Article and Find Full Text PDFModulatory Effect of Probiotics on Proinflammatory Cytokine Levels in Acrylamide-Treated Rats.
Biochem Res Int
July 2021
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
The aims of this study are to investigate the effect of acrylamide on the level of proinflammatory cytokines in the blood of acrylamide-treated rats and to find the modulatory impact of probiotics on those cytokines. Thirty-two rats were divided into four groups: rats which received 20 mg acrylamide, acrylamide with 20 mg probiotics, acrylamide with 200 mg probiotics, and standard water and food (groups 1-4, respectively). The serum levels of cytokines were measured on days 0, 15, and 30.
View Article and Find Full Text PDFAlterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats.
Toxicol Rep
November 2018
Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
Acrylamide is a vinyl monomer that is widely used for the synthesis of polyacrylamides, the treatment of drinking water, and as an additive in cosmetics. Acrylamide is also produced during the thermal processing of carbohydrate-rich foods. Although the potential toxic effects of acrylamide have been reported, few studies have evaluated biochemical parameters in blood.
View Article and Find Full Text PDFEffects of acrylamide on oxidant/antioxidant parameters and CYP2E1 expression in rat pancreatic endocrine cells.
Acta Histochem
February 2018
University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Trg Dositeja Obradovića 2, 21000 Novi Sad, Serbia. Electronic address:
Oxidative stress is one of the principle mechanism of acrylamide-induced toxicity. Acrylamide is metabolized by cytochrome P450 2E1 (CYP2E1) to glycidamide or by direct conjugation with glutathione. Bearing in mind that up to now the effects of acrylamide on oxidative stress status and CYP2E1 level in endocrine pancreas have not been studied we performed qualitative and quantitative immunohistochemical evaluation of inducible nitric oxide synthase (iNOS), superoxide dismutase 1 (SOD1), superoxide dismutase 2 (SOD2), catalase (CAT) and CYP2E1 expression in islets of Langerhans of rats subchronically treated with 25 or 50mg/kg bw of acrylamide.
View Article and Find Full Text PDFEffects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats.
Cell Mol Biol (Noisy-le-grand)
July 2017
Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Acrylamide (ACR) is a neurotoxicant, reproductive toxicant, and carcinogen in animal species. It is used in many industries and has been found to form naturally in foods cooked at high temperatures. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant whose therapeutic effect has been related to its antioxidant activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!