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Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis. | LitMetric

Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis.

Oxid Med Cell Longev

Department of Gynecological Oncology, Ren Ji Hospital, School of Medicine, Shanghai JiaoTong University, No. 145 Middle Shandong Road, Huangpu District, Shanghai 200001, China.

Published: January 2022

AI Article Synopsis

  • Ovarian cancer is a leading cause of cancer-related deaths in women, with most patients diagnosed at advanced stages, resulting in low survival rates; long noncoding RNAs (lncRNAs) like LINC00909 may aid in early diagnosis.* -
  • The study finds that elevated levels of LINC00909 in tumor and serum samples can effectively distinguish ovarian cancer from normal tissue, showcasing high sensitivity and specificity metrics.* -
  • LINC00909 is linked to cancer progression and aggressiveness, promoting cell proliferation and invasion while acting as a competing endogenous RNA that influences the epithelial-to-mesenchymal transition, suggesting its potential as a biomarker for diagnosing ovarian cancer.*

Article Abstract

Ovarian cancer (OC), the third common gynecologic malignancy, contributes to the most cancer-caused mortality in women. However, 70% of patients with OC are diagnosed at an advanced stage, of which the 5-year survival is less than 30%. Long noncoding RNAs (long ncRNAs or lncRNA), a type of RNA with exceeding 200 nucleotides in length but no protein-coding capability, have been demonstrated to involve the pathogenesis of various cancers and show considerable potential in the diagnosis of OC. In this study, we found that the LINC00909 expression in tumor and serum specimens of OC patients was elevated, determined by real-time quantitative, and droplet digital PCR. In receiver operating characteristic (ROC) analysis, our results revealed that serum LINC00909 distinguished cancers from normal ovarian tissue with 87.8% of sensitivity and 69.6% of specificity (AUC, 81.2%) and distinguished serous ovarian cancer from normal ovarian tissue with 90.0% of sensitivity and 75.9% of specificity (AUC, 84.5%). Furthermore, we observed that the tumor and serum LINC00909 level was positively associated with the International Federation of Gynecology and Obstetrics (FIGO) stage and the Eastern Cooperative Oncology Group (ECOG) score (reflecting patients' performance status). Also, patients with low serum LINC00909 level showed a longer overall (hazard ratio, HR = 1.874, = 0.0004) and progression-free (HR = 1.656, = 0.0017) survival. Functional assays indicated that the elevation of LINC00909 expression contributes to cell proliferation, migration, and invasion capability of ovarian cancer cells. Besides, we demonstrated that LINC00909 functions as a competing endogenous RNA (ceRNA) of MRC2 mRNA by sponging miR-23-3p, and thereby promotes epithelial-to-mesenchymal transition (EMT) of ovarian cancer cells. Therefore, we highlight that the LINC00909/miR-23b-3p/MRC2 axis is implicated in the pathogenesis of ovarian cancer, and serum LINC00909 may be a promising biomarker for the diagnosis of OC.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318762PMC
http://dx.doi.org/10.1155/2021/5574130DOI Listing

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