Introduction: Catalase (CAT), an antioxidant enzyme, catalyzes conversion of hydrogen peroxide to water and molecular oxygen, protecting cells against oxidative stress. The aim of this study was to investigate the possible association between polymorphism in the promoter region of the gene and leukemia risk and to determine the relationship between genotypes and CAT enzyme activities.
Material And Methods: Genotypes of 102 cases and 112 healthy controls' genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism methods. Catalase activity was measured with the method of Aebi.
Results: The frequencies of the T allele among the cases and controls were 28.4% and 25.9%, respectively ( = 0.75). The frequencies of CC, CT, and TT among cases were 57.8%, 27.4%, and 14.7%, respectively, while in controls, the frequencies of CC, CT, and TT were 54.4%, 39.3%, and 6.3%, respectively, which were not significantly different. Although CAT enzyme activity was lower in leukemia patients with TT genotypes than in controls, this did not reach statistical significance ( = 0.37).
Conclusions: This is the first report showing that polymorphism is not a genetic predisposing factor for the risk of leukemia in the Turkish population. However, additional research is needed to confirm these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314395 | PMC |
| http://dx.doi.org/10.5114/aoms.2019.89692 | DOI Listing |
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