AI Article Synopsis
- - A 60-year-old Japanese woman with a history of celiac disease was on a gluten-free diet for five years but started experiencing symptoms like loss of appetite and nausea.
- - A colonoscopy revealed ulcerative tumors in the terminal ileum, leading to a biopsy that showed large atypical lymphocytes and a specific immunohistological profile (positive for CD10 and CD20).
- - This case marks the first reported occurrence of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma occurring in a patient with celiac disease.
Article Abstract
A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD) 10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8866777 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.7876-21 | DOI Listing |
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