Dual-site transcranial magnetic stimulation (TMS) is a promising tool to measure supplementary motor area and primary motor cortex (SMA-M1) connectivity in younger and older adults, and could be used to understand the pathophysiology of movement disorders. However, test re-test reliability of dual-site TMS measures of SMA-M1 connectivity has not been established. We examined the reliability of SMA-M1 connectivity using dual-site TMS in two sessions in 30 younger and 30 older adults. For dual-site TMS, a conditioning pulse delivered to SMA (140% of active motor threshold) preceded a test pulse delivered to M1 (intensity that elicited MEPs of ~1 mV) by inter-stimulus intervals (ISI) of 6 ms, 7 ms, and 8 ms. Moderate intraclass correlation coefficients (ICC) were found for SMA-M1 connectivity at an ISI of 7 ms in younger (ICC: 0.69) and older adults (ICC: 0.68). Poor ICCs were found for SMA-M1 connectivity at ISIs of 6 ms and 8 ms in both age groups (ICC range: 0.01-0.40). We report evidence for stable measures of SMA-M1 connectivity at an ISI of 7 ms in both age groups. These findings are foundational for future research developing evidence-based interventions to strengthen SMA-M1 connectivity to improve bilateral motor control in older adults and populations with movement disorders.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuroscience.2021.07.023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neural correlates of phantom motor execution: A functional neuroimaging systematic review and meta-analysis.
Cortex
December 2024
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, USA. Electronic address:
Phantom motor execution (PME) shows promise as a new treatment for phantom limb pain (PLP) by inducing motor-related analgesia and retraining the pain network activation. However, the current understanding of the neural correlates underlying PME is limited. Databases were systematically searched for multimodal neuroimaging studies to explore the neural correlates of PME.
View Article and Find Full Text PDFAberrant connectivity of the lateralized readiness system in non-syndromic congenital mirror movements.
Clin Neurophysiol
November 2024
Department of Pathology, University of Otago, Dunedin, New Zealand.
Article Synopsis
- The study investigates the brain mechanisms involved in non-syndromic congenital mirror movements (CMM), suggesting that abnormal brain connectivity, particularly between the supplementary motor area (SMA) and motor cortex (M1), contributes to these movements.* -
- Twelve individuals with CMM were tested alongside a control group in a Go-NoGo task, using EEG to analyze differences in readiness for voluntary hand movements and brain connectivity.* -
- Results indicated that individuals with CMM had delayed movement readiness and increased connectivity in specific brain regions, hinting at possible neurocompensatory adaptations due to lifelong mirroring experiences.*
Matching supplementary motor area-primary motor cortex paired transcranial magnetic stimulation improves motor dysfunction in Parkinson's disease: a single-center, double-blind randomized controlled clinical trial protocol.
Front Aging Neurosci
August 2024
Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China.
Background: Non-invasive neuroregulation techniques have been demonstrated to improve certain motor symptoms in Parkinson's disease (PD). However, the currently employed regulatory techniques primarily concentrate on stimulating single target points, neglecting the functional regulation of networks and circuits. The supplementary motor area (SMA) has a significant value in motor control, and its functionality is often impaired in patients with PD.
View Article and Find Full Text PDFCortico-cortical connectivity is influenced by levodopa in tremor-dominant Parkinson's disease.
Neurobiol Dis
June 2024
Discipline of Psychology, College of Science, Health, Engineering and Education, Western Australia, Australia; Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Western Australia, Australia; Centre for Molecular Medicine and Innovative Therapeutics, Western Australia, Australia. Electronic address:
Resting tremor is the most common presenting motor symptom in Parkinson's disease (PD). The supplementary motor area (SMA) is a main target of the basal-ganglia-thalamo-cortical circuit and has direct, facilitatory connections with the primary motor cortex (M1), which is important for the execution of voluntary movement. Dopamine potentially modulates SMA and M1 activity, and both regions have been implicated in resting tremor.
View Article and Find Full Text PDFTable tennis experience enhances motor control in older adults: Insights into sensorimotor-related cortical connectivity.
Int J Clin Health Psychol
April 2024
Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, China.
Background: Motor control declines with age and requires effective connectivity between the sensorimotor cortex and the primary motor cortex (M1). Despite research indicating that physical exercise can improve motor control in older individuals the effect of physical exercise on neural connectivity in older adults remains to be elucidated.
Methods: Older adults with experience in table tennis and fit aerobics and individuals without such experience for comparison were recruited for the study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!