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Illuminating Plasmodium invasion by lattice-light-sheet microscopy. | LitMetric
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Illuminating Plasmodium invasion by lattice-light-sheet microscopy.

Markus Ganter Friedrich Frischknecht

Trends Parasitol

Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany; German Center for Infection Research, DZIF, partner site Heidelberg, Germany. Electronic address:

Published: September 2021

Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite-host cell interface.

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 Source
http://dx.doi.org/10.1016/j.pt.2021.07.008DOI Listing

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