Purpose: To estimate percentage of patients undergoing multiple CT exams leading to cumulative effective dose (CED) of more than 25, 50, 75 and 100 mSv in one year and assess per capita and the collective effective dose.
Methods: Data from a regional hospital network was collected retrospectively using radiation dose monitoring system at 6 facilities with 8 CT scanners. The data was analyzed to find number of patients in different dose groups, their age, gender, number of CT exams and exams needed to reach 100 mSv based on age groups.
Results: In one year 43,010 patients underwent 75,252 CT examinations. The number of exams per 1000 population was 153. Further 27% of the patients were younger than 55- years and 15.9% of them were younger than 45-year-old. A total of 0.67% of patients received a CED > 100 mSv; 3.5% had CED > 50 mSv, 11.9% with CED > 25 mSv and the maximum CED was 529 mSv. The minimum time to reach 100 mSv was a single CT exam. Seven patients received > 100 mSv in a single CT exam. 0.36% of patients had 10 or more CT exams in one year and 3.8% had 5 or more CT exams. The mean CED was 12.3 mSv, the average individual effective dose was 1.1 mSv and the collective effective dose was 521.3 person-Sv.
Conclusions: The alarming high CED received by large number of patients and with high collective dose to population requires urgent actions by all stake holders in the best interest of patient radiation safety.
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http://dx.doi.org/10.1016/j.ejrad.2021.109871 | DOI Listing |
Cardiovasc Toxicol
January 2025
Department of Morphological Sciences, State University of Maringa, Maringa, Parana, Brazil.
5-Fluorouracil (5-FU) is a chemotherapeutic that is used to treat solid tumors. However, 5-FU is associated with several side effects, including cardiotoxicity. Considering the importance of the intrinsic cardiac nervous system (ICNS) for the heart and that little is known about effects of 5-FU on this nervous system plexus, the purpose of the present study was to evaluate effects 5-FU at a low dose on the ICNS and oxidative and inflammatory effects in the heart in Wistar rats.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Radiation Oncology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, P. R. China.
Introduction: The core objective of this study was to precisely locate metastatic lymph nodes, identify potential areas in nasopharyngeal carcinoma patients that may not require radiotherapy, and propose a hypothesis for reduced target volume radiotherapy on the basis of these findings. Ultimately, we reassessed the differences in dosimetry of organs at risk (OARs) between reduced target volume (reduced CTV2) radiotherapy and standard radiotherapy.
Methods And Materials: A total of 209 patients participated in the study.
Virol J
January 2025
Medi-X Pingshan, Southern University of Science and Technology, Shenzhen, Guangdong, 518118, China.
Background: SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. This phase II study aimed to verify the efficacy and safety of SHEN26 in COVID-19 patients.
View Article and Find Full Text PDFPituitary
January 2025
Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.
Background: Arginine infusion stimulates copeptin secretion, a surrogate marker of arginine vasopressin (AVP), thereby serving as a diagnostic test in the differential diagnosis of suspected AVP deficiency (AVP-D). Yet, the precise mechanism underlying the stimulatory effect of arginine on the vasopressinergic system remains elusive. Arginine plays a significant role in the urea cycle and increases the production of urea.
View Article and Find Full Text PDFPurpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
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