Background: Limited evidence is available regarding the association between OSA and coronary plaque assessed by using quantitative coronary CT angiography.
Research Question: Are there any associations between OSA severity-related indexes and the presence and burden of coronary plaque?
Study Design And Methods: Cross-sectional data from 692 patients who underwent sleep monitoring and coronary CT angiography were used for this study. Of these patients, 120 (17.3%) underwent polysomnography, and 572 (82.7%) underwent respiratory polygraphy. Multivariable logistic and linear regression analyses were used to investigate the associations of OSA severity-related indexes with the presence, volume, and composition of plaque.
Results: In multivariable analyses, patients with moderate to severe OSA were more likely to have coronary plaques (P = .037), and plaques were more likely to contain a noncalcified plaque (NCP) component (P = .032) and a low-density NCP (LD NCP) component (P = .030). Furthermore, the apnea-hypopnea index and oxygen desaturation index as continuous variables were both associated with the presence of plaque, NCP, and LD NCP (all, P < .05). Multivariable linear regression models showed that moderate to severe OSA was associated with NCP volume (β = 50.328; P = .042) and LD NCP volume (β = 15.707; P = .011). Moreover, the apnea-hypopnea index (P = .015), oxygen desaturation index (P = .005), and percentage of nighttime with oxygen saturation < 90% (P = .017) were all significant predictors of LD NCP volume. Compared with those with no or mild OSA, patients with severe OSA had a significantly higher total plaque volume (P = .036), NCP volume (P = .036), and LD NCP volume (P = .013).
Interpretation: OSA was independently associated with the presence and burden of coronary plaque, which suggests an increased risk of coronary events.
Clinical Trial Registration: Chinese Clinical Trial Registry; No. ChiCTR-ROC-17011027; http://chictr.org.cn.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chest.2021.07.040 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Confining CoSe/MoSe2 Heterostructures in Interconnected Carbon Polyhedrons for Superior Potassium Storage.
ChemSusChem
January 2025
Jilin University, School of Materials Science and Engineering, Renmin street 5988, School of Materials Science and Engineering, Jilin University, 130022, Changchun, CHINA.
Metal selenides hold promise as feasible anode materials for potassium-ion batteries (PIBs), but still face problems such as poor potassium storage kinetics and dramatic volume expansion. Coupling heterostructure engineering with structural design could be an effective strategy for rapid and stable K+ storage. Herein, CoSe/MoSe2 heterojunction encapsulated in nitrogen-doped carbon polyhedron and further interconnected by three-dimensional nitrogen-doped carbon nanofibers (CoMoSe@NCP/NCFs) is ingeniously constructed.
View Article and Find Full Text PDFPitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial.
JAMA Cardiol
December 2024
Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston.
Article Synopsis
The nutrition profile and utility of banana puree as a liquid thickener for medically complex infants with dysphagia.
Nutr Clin Pract
February 2025
Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Introduction: Dysphagia among infants, particularly high-risk and preterm neonates, poses feeding challenges that can impact multiple systemic outcomes and delay hospital discharge. Limited therapeutic options for approved thickening agents for human milk and infant formula necessitate the exploration of alternatives, including banana puree.
Method: This study investigated the feasibility of using banana puree as a thickening agent for hospitalized infants with dysphagia.
Parenteral nutrition dependence and growth in pediatric patients with intestinal failure following transition to blenderized tube feedings: A case series.
Nutr Clin Pract
February 2025
Center for Advanced Intestinal Rehabilitation, Boston Children's Hospital, Boston, Massachusetts, USA.
Article Synopsis
- * Twelve children met the criteria for the study, with most having undergone small bowel resection; after the switch to BTF, 25% achieved enteral autonomy, and 58% showed a decrease in PN energy intake.
- * The transition to BTF did not significantly alter growth patterns or stool frequency, suggesting that BTF can be a beneficial option for older children with IF.
Interscan reproducibility of computed tomography derived coronary plaque volume measurements.
J Cardiovasc Comput Tomogr
November 2024
Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Article Synopsis
- Coronary computed tomography angiography (CCTA) is useful for analyzing coronary atherosclerotic plaques, but previous studies on the consistency of plaque volume measurements between scans are limited.
- In a study involving 101 patients, CCTA scans were performed twice with a one-hour interval using identical protocols, and plaque volumes were assessed using semi-automated software.
- Results showed high correlation for total, non-calcified, and calcified plaques, but lower for low-density non-calcified plaques, with reproducibility influenced by image quality, reconstruction settings, and lesion location, particularly in left anterior descending (LAD) arteries.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!