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Investigation of Anti-Apoptotic Effects and Mechanisms of Astragaloside IV in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
CNS Neurosci Ther
January 2025
Qingshan Lake Science and Technology Innovation Center, Hangzhou Medical College, Hangzhou, China.
Background: Ischemic stroke is a prevalent and life-threatening cerebrovascular disease that is challenging to treat and associated with a poor prognosis. Astragaloside IV (AS-IV), a primary bioactive component of Astragali radix, has demonstrated neuroprotective benefits in previous studies. This study aimed to explore the mechanisms through which AS-IV may treat cerebral ischemia-reperfusion injury (CIRI).
View Article and Find Full Text PDFTargeted Liposomal Co-Delivery Dopamine with 3-n-Butylphthalide for Effective Against Parkinson's Disease in Mice Model.
Int J Nanomedicine
December 2024
School of Pharmacy, Chengdu Medical College, Chengdu, 610500, People's Republic of China.
Introduction: Parkinson's disease (PD) is a multifactor-induced neurodegenerative disease with high incidence in the elderly population. We found for the first time that the combination of dopamine (DA) and 3-n-butylphthalide (NBP) has great potential for the synergistic treatment of PD. To further improve the therapeutic performance of the drugs, a brain-targeting liposomal co-delivery system encapsulating NBP and DA ((NBP+DA)-Lips-RVG29) was designed using a rabies virus polypeptide with 29 amino acids (RVG29) as the targeting ligand.
View Article and Find Full Text PDFEfficacy and safety of DL-3-N-butylphthalide in the treatment of ischemic poststroke aphasia: A randomized clinical trial.
Ann Clin Transl Neurol
December 2024
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Article Synopsis
- This study investigates the effectiveness and safety of a drug called DL-3-N-butylphthalein (NBP) in treating poststroke aphasia, which significantly affects communication and daily life for many patients following a stroke.
- Conducted over six months with 118 patients, the results showed that those receiving NBP had better improvements in language skills compared to a placebo group, with no significant increase in liver function issues.
- The findings suggest that NBP may enhance recovery in stroke-related language impairment by boosting levels of certain neurotransmitters, indicating a potential new direction for treatment.
Assessment of the impact of combining butylphthalide and atorvastatin on neurological function, quality of life and vascular endothelial function in individuals diagnosed with acute cerebral infarction.
Pak J Pharm Sci
September 2024
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Acute cerebral infarction poses a significant health risk and effective treatment is crucial. This randomized controlled trial assessed the impact of combining Butylphthalide and Atorvastatin on neurological function, quality of life and vascular endothelial function in 124 individuals with acute cerebral infarction. Participants were randomized into control and experimental groups, with the latter receiving the combination therapy.
View Article and Find Full Text PDFImpact of NBP on acute ischemic stroke: Tracking therapy effect on neuroinflammation.
Int Immunopharmacol
December 2024
Department of Neurology, Punan Hospital, Pudong New District, Shanghai 200125, China; Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address:
Background: Ischemic stroke is the leading cause of death and long-term disability worldwide. After stroke, microglia exhibit not only pro-inflammatory phenotype to aggravate the neuroinflammation, but also anti-inflammatory phenotype to play a neuroprotective role. Studies on the spatial and temporal changes in microglia and the underlying mechanisms help to elucidate the inflammatory cascade after stroke.
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