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Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications. | LitMetric

AI Article Synopsis

  • Dicarboxylic amino acid-based surfactants combined with HTAB create various aggregates, including liquid crystals, gels, and clear isotropic phases depending on their composition and concentration.
  • Studies using polarizing optical microscopy and FE-SEM show distinct liquid crystalline patterns and surface morphologies of these aggregates.
  • The gels display low toxicity to human lymphocytes and mouse skin, along with significant antibacterial effects against Staphylococcus aureus, indicating potential for use in topical drug delivery.

Article Abstract

Dicarboxylic amino acid-based surfactants (N-dodecyl derivatives of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) form a variety of aggregates. Composition and concentration-dependent mixtures exhibit liquid crystal, gel, precipitate, and clear isotropic phases. Liquid crystalline patterns, formed by surfactant mixtures, were identified by polarizing optical microscopy. FE-SEM studies reveal the existence of surface morphologies of different mixed aggregates. Phase transition and associated weight loss were found to depend on the composition where thermotropic behaviours were revealed through combined differential scanning calorimetry and thermogravimetric studies. Systems comprising more than 60 mol% HTAB demonstrate shear-thinning behaviour. Gels cause insignificant toxicity to human peripheral lymphocytes and irritation to bare mouse skin; they do not display the symptoms of cutaneous irritation, neutrophilic invasion, and inflammation (erythema, edema, and skin thinning) as evidenced by cumulative irritancy index score. Gels also exhibit substantial antibacterial effects on Staphylococcus aureus, a potent causative agent of skin and soft tissue infections, suggesting its possible application as a vehicle for topical dermatological drug delivery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324821PMC
http://dx.doi.org/10.1038/s41598-021-94777-2DOI Listing

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