AI Article Synopsis
- The study measured fractional hepatic blood volume (HBV) and hepatic blood flow (HBF) in patients with cirrhosis and healthy individuals before and after a meal.
- Fasting HBV was significantly lower in cirrhosis patients compared to healthy subjects, and while HBF increased in both groups post-meal, HBV did not decrease in cirrhosis patients as it did in healthy ones.
- The findings suggest that patients with cirrhosis exhibit abnormal blood volume responses to eating, indicating a disrupted hemodynamic response to normal physiological changes.
Article Abstract
Background & Aims: The aim was to measure fractional hepatic blood volume (HBV) and hepatic blood flow (HBF) before and after a meal in patients with cirrhosis ( = 7) and healthy persons ( = 6).
Methods: Catheters were placed in a radial artery and a hepatic vein for blood sampling and a peripheral vein for indocyanine green (ICG) infusion. A 6-min positron emission tomography (PET) liver scan was performed after inhalation of 1000 MBq O-CO and repeated after ingestion of a standard meal. HBV was calculated as the O-CO concentration in liver tissue (PET) divided by that in arterial blood. HBF was calculated from ICG infusion rate and arterial and hepatic venous blood concentrations according to Fick's principle.
Results: Mean fasting HBV was 14 mL blood/100 mL liver tissue in patients with cirrhosis and 21 mL blood/100 mL liver tissue in healthy subjects ( < .01). Mean HBV did not change postprandially in patients with cirrhosis (13 mL blood/100 mL liver tissue) but decreased in healthy subjects (17 mL blood/100 mL liver tissue; = .02). Mean fasting HBF was 1.5 L blood/min in patients with cirrhosis and 1.1 L blood/min in healthy subjects and increased in both groups of subjects to 1.8 L blood/min.
Conclusions: Fasting HBV was lower in patients with cirrhosis and did not decrease postprandially as it did in the healthy controls although the HBF increased equally. Patients with cirrhosis thus have a disturbed hemodynamic response to normo-physiological changes such as a meal.
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| http://dx.doi.org/10.1080/00365521.2021.1953128 | DOI Listing |
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