AI Article Synopsis
- Organoid research is advancing our knowledge of human development, diseases, and drug development, while also raising ethical concerns regarding its application.
- Interviewed patients and parents largely supported organoid use, but viewed brain and gonadal organoids as morally distinct, indicating mixed feelings about certain types of research.
- Patients emphasized the importance of ethical oversight and informed consent in organoid studies, believing that as long as research is conducted responsibly, it holds significant potential for medical advancements.
Article Abstract
Organoid research is enhancing understanding of human development and diseases as well as aiding in medication development and selection, raising hopes for even more future therapeutic options. Nevertheless, this work raises important ethical issues and there is a paucity of data regarding patients' perspectives on them. We report on 60 interviews with adult patients or parents of pediatric patients from diverse disease populations who receive medical care at a major academic research institution in the United States. Interviewees expressed broad support for organoid development and use. However, patients viewed brain organoids, and sometimes gonadal organoids, as morally distinct; and some organoid research poses moral concerns. Nonetheless, patients generally understood the potential value of such research and approved of it, provided it was aimed at good intent and conducted with ethical oversight and a robust consent process. These data should help inform conceptual and policy deliberations about appropriate organoid use.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365094 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2021.07.004 | DOI Listing |
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