A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323910 | PMC |
| http://dx.doi.org/10.1371/journal.pbio.3001342 | DOI Listing |
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