AI Article Synopsis
- The chapter outlines the process of creating a controlled human hookworm infection (CHHI) model in both endemic and non-endemic regions to speed up vaccine development.
- It highlights the collaboration with the Human Hookworm Vaccine Initiative (HHVI), which aims to establish a human hookworm vaccination/challenge model (HVCM) in Brazil.
- This model will enable rapid assessment of vaccine efficacy in adults, facilitating the selection of the best candidates for future pediatric trials while minimizing participant numbers.
Article Abstract
In this chapter, we describe the scientific, technical, clinical and regulatory aspects of establishing a controlled human hookworm infection (CHHI) model in non-endemic and endemic geographical regions, to facilitate a pathway towards accelerated vaccine development. The success achieved in establishing the CHHI platform specifically allows the Human Hookworm Vaccine Initiative (HHVI) to accelerate its progress by establishing a human hookworm vaccination/challenge model (HVCM) in a hookworm endemic area of Brazil. The HVCM will permit the rapid and robust determination of clinical efficacy in adults, allowing for early selection of the most efficacious human hookworm vaccine (HHV) candidate(s) to advance into later-stage pivotal paediatric clinical trials and reduce the overall number of participants required to assess efficacy (Diemert et al. 2018).
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| http://dx.doi.org/10.1007/82_2021_237 | DOI Listing |
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