AI Article Synopsis
- Henoch-Schönlein purpura nephritis (HSN) affects the kidneys and involves symptoms like hematuria and proteinuria; the study aimed to analyze data from HSN patients who had renal biopsies to see how various factors impact outcomes.
- The study evaluated 72 HSN patients over a ten-year period, categorized their biopsy results, and compared clinical data, treatment approaches, and both short- and long-term outcomes.
- Key findings indicated that conditions like scrotal involvement, hypertension, and low creatinine clearance were linked to worse outcomes, suggesting the need for closer monitoring and considering specific treatments like cyclosporin-A and cyclophosphamide for patients unresponsive to steroids.
Article Abstract
Introduction: Henoch-Schönlein purpura nephritis (HSN) is defined as Henoch-Schönlein purpura with kidney involvement, including hematuria and/or proteinuria. The aim of this study was to evaluate the data of HSN patients who underwent renal biopsy, and compare the main clinical and laboratory parameters that may affect renal biopsy findings, treatment protocols, and short- and long-term outcome of those patients.
Methods: Biopsies performed in 72 HSN patients between January 2007 to January 2017 were retrospectively evaluated. They were divided into two groups according to renal biopsy classification of the International Study of Kidney Disease in Children. Renal outcome, clinical and laboratory parameters, treatment protocols, and outcome were compared between groups. Short- and long-term follow-up of patients were evaluated.
Results: Of 72 patients, 47 were male (65.3%) and 44 (61.1%) were ≤10 years of age. Neutrophil-lymphocyte ratio was found higher in patients with scrotal involvement (p=0.042). Short-term unfavorable outcome was significantly higher in patients with scrotal involvement (p=0.038). Patients with hypertension and decreased creatinine clearance were found to have more unfavorable outcomes in long-term follow-up (p=0.029, p=0.040).
Conclusion: Cyclosporin-A and cyclophosphamide could be effective in steroid unresponsive HSN patients. Patients with scrotal involvement, decreased creatinine clearance, and hypertension should be closely monitored for sequelae of HSN.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943869 | PMC |
| http://dx.doi.org/10.1590/2175-8239-JBN-2021-0035 | DOI Listing |
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