Detouring adrenergic stimulation to induce adipose thermogenesis.

Nat Rev Endocrinol

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

Published: October 2021

Harnessing the thermogenic, energy-expending capacity of adipocytes has the potential to combat metabolic disorders. Although β-adrenergic receptor agonists are the best-known activators of thermogenesis, they carry considerable cardiovascular risks. A new study demonstrates the ability of G protein-coupled receptor 3 to intrinsically drive adipose thermogenesis independent of β-adrenergic receptor signalling.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457525PMC
http://dx.doi.org/10.1038/s41574-021-00546-6DOI Listing

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