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Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex. | LitMetric

AI Article Synopsis

  • - Integration of multi-frequency sounds is essential for syllable recognition in speech, relying on the precise timing of sound components and their neural correlates remain largely unexplored.
  • - Research shows that mouse secondary auditory cortex (A2) is preferentially activated by harmonic sounds, with responses weakening when sound timing is altered, and that disabling specific interneurons can widen the integration window for these harmonics.
  • - A2 contains stable networks of neurons that are optimized for encoding harmonic sounds and is crucial for tasks requiring discrimination of such sounds, indicating its key role in processing vocalizations.

Article Abstract

Integration of multi-frequency sounds into a unified perceptual object is critical for recognizing syllables in speech. This "feature binding" relies on the precise synchrony of each component's onset timing, but little is known regarding its neural correlates. We find that multi-frequency sounds prevalent in vocalizations, specifically harmonics, preferentially activate the mouse secondary auditory cortex (A2), whose response deteriorates with shifts in component onset timings. The temporal window for harmonics integration in A2 was broadened by inactivation of somatostatin-expressing interneurons (SOM cells), but not parvalbumin-expressing interneurons (PV cells). Importantly, A2 has functionally connected subnetworks of neurons preferentially encoding harmonic over inharmonic sounds. These subnetworks are stable across days and exist prior to experimental harmonics exposure, suggesting their formation during development. Furthermore, A2 inactivation impairs performance in a discrimination task for coincident harmonics. Together, we propose A2 as a locus for multi-frequency integration, which may form the circuit basis for vocal processing.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322099PMC
http://dx.doi.org/10.1038/s41467-021-24758-6DOI Listing

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