Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435018 | PMC |
| http://dx.doi.org/10.1016/j.jdiacomp.2021.107994 | DOI Listing |
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