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Discovery of novel substituted (Z)-N'-hydroxy-3-(3-phenylureido)benzimidamide derivatives as multifunctional molecules targeting pathological hallmarks of Alzheimer's disease.
Eur J Med Chem
December 2024
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU) Varanasi, U.P., 221005, India. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to significant cognitive decline and motor dysfunction due to the loss of cholinergic neurons, with current medications only providing temporary relief of symptoms.
- Novel compounds based on rivastigmine (such as 3q and 6e) were developed and shown to effectively inhibit key enzymes involved in AD, exhibit antioxidant properties, and prevent the aggregation of tau and Aβ proteins.
- These compounds also reduced inflammation in brain cells and restored memory function in animal models, showing increased expression of neuroprotection markers, indicating their potential for treating AD more effectively than existing medications.
Gradient-induced long-range optical pulling force based on photonic band gap.
Light Sci Appl
April 2024
Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China.
Optical pulling provides a new degree of freedom in optical manipulation. It is generally believed that long-range optical pulling forces cannot be generated by the gradient of the incident field. Here, we theoretically propose and numerically demonstrate the realization of a long-range optical pulling force stemming from a self-induced gradient field in the manipulated object.
View Article and Find Full Text PDFSelf-induced Hot Water Finger Burn Trying to Get Feeling Back after Ropivacaine Block.
Plast Reconstr Surg Glob Open
April 2024
Division of Plastic Surgery, Dalhousie University, Saint John, Canada.
Article Synopsis
- A patient developed severe hot water burns after undergoing an infraclavicular block for a scaphoid fracture, highlighting the issue of self-induced injuries that may go unreported.
- Some individuals may be too embarrassed to admit their injuries, which can lead to misdiagnosis by healthcare professionals if the full history is not disclosed.
- The article aims to educate medical staff on recognizing key signs of self-induced hot water burns to ensure accurate diagnosis and treatment, including identifying the burn lines, hyperemia, and blisters.
Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer's Disease Therapy.
ACS Chem Neurosci
February 2024
Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology-Banaras Hindu University, Varanasi 221005, India.
An efficient and promising method of treating complex neurodegenerative diseases like Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of quinazoline derivatives ( to ) were rationally designed, synthesized, and biologically evaluated as multitargeted directed ligands against human cholinesterase (hChE) and human β-secretase (hBACE-1) that exhibit moderate to good inhibitory effects. Compounds , , and from the series demonstrated balanced and significant inhibition against these targets.
View Article and Find Full Text PDFOscillations and Cavity Modes in the Circular Hydraulic Jump.
Phys Rev Lett
November 2023
Université de Lille, CNRS, Centrale Lille, Université Polytechnique Hauts-de-France, UMR 8520-IEMN-Institut d'Electronique de Microélectronique et de Nanotechnologie, F-59000 Lille, France.
We report spontaneous oscillations of circular hydraulic jumps created by the impact of a submillimeter water jet on a solid disk. The jet flow rate is shown to condition the occurrence of the oscillations while their period is independent of this parameter. The period, however, varies linearly with the disk radius.
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