A total synthesis of (-)-strempeliopine is disclosed that enlists a powerful SmI-mediated and BF·OEt-initiated dearomative transannular radical cyclization onto an indole by an -acyl α-aminoalkyl radical that is derived by single electron reduction of an in situ generated iminium ion for formation of a quaternary center and the strategic C19-C2 bond in its core structure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405276 | PMC |
| http://dx.doi.org/10.1021/jacs.1c06913 | DOI Listing |
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