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A Novel Statistical Method for Unmasking Sex-Specific Genomics Signatures in Complex Traits.
Genet Epidemiol
January 2025
CERVO Brain Research Centre, Québec City, Québec, Canada.
Genotype-phenotype association studies have advanced our understanding of complex traits but often overlook sex-specific genetic signals. The growing awareness of sex-specific influences on human traits and diseases necessitates tailored statistical methodologies to dissect these genetic intricacies. Rare genetic variants play a significant role in disease development, often exhibiting stronger per-allele effects than common variants.
View Article and Find Full Text PDFNavigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity.
Immunometabolism (Cobham)
January 2025
Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within the oral epithelium, elucidating their roles in orchestrating immune responses and influencing tissue plasticity. By synthesizing current knowledge, we aim to unravel the molecular intricacies that govern this interplay, with a focus on potential therapeutic implications for oral health and diseases.
View Article and Find Full Text PDFExploring links between visuospatial ability and anatomy learning in education: A bibliometric analysis and scientific mapping.
Narra J
December 2024
Department of Medical Education, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia.
The field of medical education faces a significant challenge in teaching human anatomy, a fundamental aspect of medical science that is often perceived as complex and demanding. Understanding the shapes and anatomical structure locations is crucial for students to master the intricacies of anatomy. Visuospatial ability, which involves comprehending three-dimensional structures and their spatial relationships, plays a pivotal role in anatomy learning.
View Article and Find Full Text PDFFacilitators and barriers to interprofessional learning, collaboration, and identity development during interprofessional internship in rehabilitation care: A qualitative study.
J Interprof Care
January 2025
Research group, FAITH research, Leeuwarden, Groningen, The Netherlands.
The growing complexity of care and healthcare workforce shortages in the Netherlands necessitates exploring interprofessional collaboration (IPC). However, the predominant single-professional education may result in a professional identity (PI) among healthcare students, which may not support successful IPC. Internships in student-run interprofessional learning wards (SR-IPLW) could foster interprofessional identity (IPI) development.
View Article and Find Full Text PDFMachine learning and multi-omics in precision medicine for ME/CFS.
J Transl Med
January 2025
Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, 3052, Australia.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and multifaceted disorder that defies simplistic characterisation. Traditional approaches to diagnosing and treating ME/CFS have often fallen short due to the condition's heterogeneity and the lack of validated biomarkers. The growing field of precision medicine offers a promising approach which focuses on the genetic and molecular underpinnings of individual patients.
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