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AbstractChanging climates are driving population declines in diverse animals worldwide. Winter conditions may play an important role in these declines but are often overlooked. Animals must not only survive winter but also preserve body condition, a key determinant of growing season success.
View Article and Find Full Text PDFA goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions.
Front Mol Biosci
November 2024
Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
While many researchers can design knockdown and knockout methodologies to remove a gene product, this is mainly untrue for new chemical inhibitor designs that empower multifunctional DNA Damage Response (DDR) networks. Here, we present a robust Goldilocks (GL) computational discovery protocol to efficiently innovate inhibitor tools and preclinical drug candidates for cellular and structural biologists without requiring extensive virtual screen (VS) and chemical synthesis expertise. By computationally targeting DDR replication and repair proteins, we exemplify the identification of DDR target sites and compounds to probe cancer biology.
View Article and Find Full Text PDFInnovative surgical management of gestational gigantomastia.
Arch Clin Cases
December 2024
Division of General Surgery, McGill University, Montreal, Quebec, Canada.
Gigantomastia is a rare condition characterized by excessive breast enlargement, which can lead to physical and psychological distress. Gestational gigantomastia (GG) occurs during pregnancy, often presenting significant management challenges. This case contributes to the limited literature on GG management by highlighting the successful use of the Goldilocks technique combined with free nipple grafting, offering insights into an effective surgical approach.
View Article and Find Full Text PDFOptimal levels of sleep, sedentary behaviour, and physical activity needed to support cognitive function in children of the early years.
BMC Pediatr
November 2024
School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada.
Background: Sleep, sedentary behaviour, physical activity, and the composition of these movement behaviours across the 24-h day are associated with cognitive function in early years children. This study used a Goldilocks day compositional data analysis approach to identify the optimal duration of sleep, sedentary behaviour, light physical activity, and moderate-to-vigorous physical activity associated with desired cognitive function outcomes in early years children.
Methods: This cross-sectional study included 858 children aged 2.
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