Background: Polymorphisms of the vitamin D receptor (VDR) are associated with calcium oxalate (CaOx) nephrolithiasis in humans.
Objectives: To investigate the association between VDR polymorphisms and susceptibility to CaOx urolithiasis in dogs.
Animals: Thirty-five dogs with CaOx urolithiasis were compared with 40 stone-free dogs.
Methods: This was a case-control study. Two VDR gene polymorphisms (rs851998024 and rs852900542) were detected by specific TaqMan real-time polymerase chain reaction assay, and their relationship with serum 1,25-dihydroxyvitamin D, serum and urinary electrolyte concentrations was evaluated.
Results: The distribution of the rs852900542 polymorphism was significantly different between the case and the control dogs (x = 6.369, P = .04). Dogs with a CC or CT genotype had an increased risk of CaOx stones than those with the TT genotype (odds ratio = 3.82, 95% confidence interval 1.04-13.98). The CaOx dogs with the TT genotype had a significantly lower urinary calcium-to-creatinine ratio than the CT+CC genotypes. 1,25-(OH)2D concentrations did not differ between the cases and the controls (308.7 ± 217.4 vs 286.7 ± 185.1 pg/mL, P = .45).
Conclusions And Clinical Importance: This finding suggests that vitamin D metabolism might play a role in CaOx stone formation in dogs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478019 | PMC |
| http://dx.doi.org/10.1111/jvim.16225 | DOI Listing |
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