The effects of clinical and angiographic aspects of coronary artery disease on the cardiac autonomic function: a single-center prospective cohort study.

Background: Autonomic malfunction is linked to elevated cardiovascular morbidity and mortality. Various patient characteristics can alter the cardiac autonomic function therefore, using a prospective observational study, we aimed to assess the effects of different clinical and angiographic factors of coronary artery disease (CAD) patients on the cardiac autonomic function evaluated by heart rate variability (HRV) measurement.

Methods And Patients: 100 patients undergoing coronary angiography when clinically indicated were enrolled. A short-term 5-minute HRV measurement was performed by CheckMyheart™ handheld HRV device manufactured by DailyCare BioMedical Inc, Taiwan. HRV data were fed to CheckMyheart™ 5-min HRV analysis software and interpreted based on the standard methods for HRV measurement as discussed in the Task Force of the European Society of Cardiology (ESC) and The North American Society of Pacing and Electrophysiology (NAPSE). Coronary angiography was done with an emphasis on SYNTAX (SX) score calculation.

Results: The mean age of the recruited patients was 56.89±10.75 years with 85% of them were males and the mean SX score 13.11±8.52. Multivariate regression analysis of the different patient clinical and angiographic characteristics affecting HRV showed that CAD type either single or multi-vessel and SX score were the major independent variables affecting HRV in patients with CAD.

Conclusion: The complexity of CAD measured by SX score was the main independent predictor affecting the cardiac autonomic function estimated by HRV measurement.