AI Article Synopsis
- Recent studies identified Clone 1 of Mycobacterium abscessus subspecies massiliense (M. massiliense) as prevalent among cystic fibrosis (CF) patients and linked to outbreaks in the US and UK, as well as an epidemic in Brazil affecting skin.
- A survey of Mycobacteria isolates showed that 39% of non-CF patients had Clone 1, with a lower prevalence (17%) in CF-associated isolates; genomic analyses revealed similar SNP patterns in outbreak and sporadic isolates.
- Pulmonary outbreak isolates exhibited more antimicrobial resistance mutations than sporadic isolates, indicating the need for further research to understand transmission pathways of Clone 1 among CF and non-CF populations in
Article Abstract
Recent studies have characterized a dominant clone (Clone 1) of Mycobacterium abscessus subspecies massiliense (M. massiliense) associated with high prevalence in cystic fibrosis (CF) patients, pulmonary outbreaks in the United States (US) and United Kingdom (UK), and a Brazilian epidemic of skin infections. The prevalence of Clone 1 in non-CF patients in the US and the relationship of sporadic US isolates to outbreak clones are not known. We surveyed a reference US Mycobacteria Laboratory and a US biorepository of CF-associated Mycobacteria isolates for Clone 1. We then compared genomic variation and antimicrobial resistance (AMR) mutations between sporadic non-CF, CF, and outbreak Clone 1 isolates. Among reference lab samples, 57/147 (39%) of patients with M. massiliense had Clone 1, including pulmonary and extrapulmonary infections, compared to 11/64 (17%) in the CF isolate biorepository. Core and pan genome analyses revealed that outbreak isolates had similar numbers of single nucleotide polymorphisms (SNPs) and accessory genes as sporadic US Clone 1 isolates. However, pulmonary outbreak isolates were more likely to have AMR mutations compared to sporadic isolates. Clone 1 isolates are present among non-CF and CF patients across the US, but additional studies will be needed to resolve potential routes of transmission and spread.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319421 | PMC |
| http://dx.doi.org/10.1038/s41598-021-94789-y | DOI Listing |
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