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Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis.
BMC Health Serv Res
January 2025
Department of School and Social Adaptation Studies, Faculty of Education, Université de Sherbrooke, Sherbrooke, Canada.
Background: The COVID-19 pandemic necessitated the rapid availability of evidence to respond in a timely manner to the needs of practice settings and decision-makers in health and social services. Now that the pandemic is over, it is time to put in place actions to improve the capacity of systems to meet knowledge needs in a situation of crisis. The main objective of this project was thus to develop an action plan for the rapid syntheses of evidence in times of health crisis in Quebec (Canada).
View Article and Find Full Text PDFDecisional capacity to consent to treatment in children and adolescents: A systematic review.
Psychiatry Res
December 2024
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy. Electronic address:
Obtaining informed consent in vulnerable populations like children and adolescents, is a relevant issue and raises ethical concerns. Minors are considered unable to consent to treatment, and permission from guardians is required for them. Nevertheless, several studies have been carried out on the competence of pediatric patients, with mixed results.
View Article and Find Full Text PDFInfluence of Ageing on the Pharmacodynamics and Pharmacokinetics of Chronically Administered Medicines in Geriatric Patients: A Review.
Clin Pharmacokinet
January 2025
Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
As people age, the efficiency of various regulatory processes that ensure proper communication between cells and organs tends to decline. This deterioration can lead to difficulties in maintaining homeostasis during physiological stress. This includes but is not limited to cognitive impairments, functional difficulties, and issues related to caregivers which contribute significantly to medication errors and non-adherence.
View Article and Find Full Text PDFExtracellular vesicles: essential agents in critical bone defect repair and therapeutic enhancement.
Mol Biol Rep
January 2025
Pediatric Cell, and Gene Therapy Research Center Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Bone serves as a fundamental structural component in the body, playing pivotal roles in support, protection, mineral supply, and hormonal regulation. However, critical-sized bone injuries have become increasingly prevalent, necessitating extensive medical interventions due to limitations in the body's capacity for self-repair. Traditional approaches, such as autografts, allografts, and xenografts, have yielded unsatisfactory results.
View Article and Find Full Text PDFMechanical analysis of cerclage as a treatment for cervical insufficiency.
Arch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Ulsan University Hospital, University of Ulsan, College of Medicine, 25 Daehakbyeongwon-ro, Dong-gu, Ulsan, 44033, South Korea.
Background: The primary treatment for cervical insufficiency is cervical cerclage (mechanical support) with vaginal progesterone (biochemical support). Cerclage is a surgical procedure that mechanically increases the tensile capacity of the cervix. Therefore, it is necessary to analyse the effects of cerclage from a mechanical point of view.
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