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Defective Slc7a7 transport reduces erythropoietin compromising erythropoiesis.
Mol Med
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Background: Lysinuric protein intolerance is a rare autosomal disorder caused by mutations in the Slc7a7 gene that lead to impaired transport of neutral and basic amino acids. The gold standard treatment for lysinuric protein intolerance involves a low-protein diet and citrulline supplementation. While this approach partially improves cationic amino acid plasma levels and alleviates some symptoms, long-term treatment is suggested to be detrimental and may lead to life-threatening complications characterized by a wide range of hematological and immunological abnormalities.
View Article and Find Full Text PDFGlucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.
Int J Pharm
January 2025
Laboratory of Biotherapy, National Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Renmin Nanlu 17, Chengdu 610041, Sichuan, China. Electronic address:
Lipid nanoparticles (LNPs) are among the most promising non-viral mRNA delivery systems for gene therapeutic applications. However, the in vivo delivery of LNP-mRNA remains challenging due to multiple intrinsic barriers that hinder LNPs from reaching their target cells. In this study, we sought to enhance LNP delivery by manipulating intrinsic regulatory mechanisms involved in their metabolism.
View Article and Find Full Text PDFBaicalein-loaded porous silk fibroin microspheres modulate the senescence of nucleus pulposus cells through the NF-κB signaling pathway.
Colloids Surf B Biointerfaces
January 2025
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510130, PR China; Guangzhou University of Chinese Medicine Postdoctoral Research Station, Guangzhou 510130, PR China. Electronic address:
Intervertebral disc degeneration (IVDD), an age-associated degenerative condition, significantly contributes to low back pain, thereby adversely affecting individual health and quality of life, while also imposing a substantial societal burden. Baicalein, a natural flavonoid derived from Scutellaria baicalensis Georgi, demonstrates a range of pharmacological activities, including antioxidant, anti-inflammatory, anti-tumor, and antibacterial properties. This positions it as a promising candidate for the treatment of IVDD through intradiscal drug delivery.
View Article and Find Full Text PDFTemperature-driven development and reproduction in Cacopsylla citrisuga (Hemiptera: Psyllidae): insights from an age-stage, two-sex life table analysis.
J Econ Entomol
January 2025
Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, P.R. China.
The citrus pest Cacopsylla citrisuga (Yang & Li), a vector for Citrus Huanglongbing (HLB), exhibits distinct sensitivity to temperature variations. This study utilized an age-stage, 2-sex life table to evaluate the development and reproduction of C. citrisuga across 5 temperatures (17, 20, 25, 28, and 31 °C).
View Article and Find Full Text PDFscHNTL: single-cell RNA-seq data clustering augmented by high-order neighbors and triplet loss.
Bioinformatics
January 2025
School of Computing and Artificial Intelligence, Southwest Jiaotong University, Sichuan 611756, China.
Motivation: The rapid development of single-cell RNA sequencing (scRNA-seq) has significantly advanced biomedical research. Clustering analysis, crucial for scRNA-seq data, faces challenges including data sparsity, high dimensionality, and variable gene expressions. Better low-dimensional embeddings for these complex data should maintain intrinsic information while making similar data close and dissimilar data distant.
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