Novel azoles with potent antileishmanial activity.

To investigate the antileishmanial activity of novel azole compounds against , which causes deadly visceral leishmaniasis disease. A focused azole-based library was screened against both promastigotes and amastigotes forms of strains in flat-bottomed 96-well tissue culture plates and J774A.1 macrophage cell-line infected with . The comprehensive screening of azole-based library against strains provided novel hits, which can serve as a good starting point to initiate hit to lead optimization campaign. Hits identified from azole-based library exhibited potent activity against promastigotes and amastigotes of . These potent novel azole hits could be a good starting point to carry out for further medicinal chemistry exploration for antileishmania program.