We report an unusual case of incomplete endothelialization of the Watchman device >3 years after its implantation. Animal data suggest that device endothelialization occurs ∼45 days post-implantation; however, data on humans are lacking. Guidelines on anticoagulation are based on expectation from animal studies. ().
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| http://dx.doi.org/10.1016/j.jaccas.2020.09.022 | DOI Listing |
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Comparative Endothelialization of the Watchman Plug Device and LACBES Pacifier Occluder after Left Atrial Appendage Closure.
Rev Cardiovasc Med
December 2024
Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China.
Article Synopsis
- Left atrial appendage closure (LAAC) is an alternative for patients with nonvalvular atrial fibrillation (NVAF) to avoid oral anticoagulants, but issues like incomplete device endothelialization (IDE) can lead to complications.
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- Results showed that the LACBES occluder had a higher IDE rate at both 3 and 6 months compared to the Watchman device, indicating that it takes longer for the LACBES to achieve complete endothelialization after LAAC.
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CJC Open
December 2024
Schulich Heart Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Background: Cardiac computed tomography imaging with contrast is being used increasingly to image left atrial appendage occlusion (LAAO) devices. Contrast flow across a device, also known as a transfabric leak (TFL), may indicate a lack of complete LAAO-device endothelialization. The data on the rate, predictors, and clinical events associated with TFL are limited.
View Article and Find Full Text PDFClinical incidence and relevance of incomplete endothelialization in atrial fibrillation patients with Left Atrial Appendage Closure.
BMC Cardiovasc Disord
August 2024
Department of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: The objective of this study is to investigate the incidence, potential risk factors, and clinical outcomes of incomplete device endothelialization (IDE) in atrial fibrillation (AF) patients undergoing Watchman left atrial appendage closure (LAAC).
Methods: In this study, 68 AF patients who underwent successful implantation of the Watchman device without peri-device leak (PDL) during follow-up were included. The endothelialization status was assessed using Transesophageal echocardiography (TEE) and LAA computed tomography angiography (CTA) at 6 weeks and 6 months post-implantation.
Peri-device leakage and delayed endothelialization of the Watchman device: a computed tomography study.
Eur Radiol
November 2024
Senior Department of Cardiology, The Sixth Medical Center of PLA General Hospital, 6 Fucheng Road, Haidian District, Beijing, 100048, China.
Objectives: This study aimed to explore the endothelialization process and assess the potential association between endothelialization and peri-device leak (PDL) following Watchman implantation via a quantitative method.
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Circ Cardiovasc Interv
May 2024
Department of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, China.
Background: The prognostic impact of left atrial appendage (LAA) patency, including those with and without visible peri-device leak (PDL), post-LAA closure in patients with atrial fibrillation, remains elusive.
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