A 54-year-old male with history of end-stage renal disease secondary to hypertension on hemodialysis with moderate aortic valve insufficiency presented with progressive exertional dyspnea and lower extremity edema over several weeks. Relevant history included hospitalization for bacteremia secondary to dialysis catheter line infection 6 months prior. ().
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http://dx.doi.org/10.1016/j.jaccas.2020.05.076 | DOI Listing |
Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonuclease 1 (APE1) initiates repair of AP-sites by cleaving the DNA backbone at the AP-site via its endonuclease activity. Here, we investigated the functional role of the APE1 active site residue N174 that contacts the AP-site during catalysis.
View Article and Find Full Text PDFCureus
December 2024
Department of Orthopaedic Surgery, Seifu Hospital, Sakai, JPN.
Most cases of patellar dislocation can be reduced spontaneously or manually without sedation. To date, only one case of arthroscopic reduction for a lateral locked patellar dislocation has been reported, with a short follow-up period. Herein, we report the case of a 22-year-old man with a lateral locked patellar dislocation for whom we performed arthroscopic reduction and repair of the medial structure, which stabilized the patella medially.
View Article and Find Full Text PDFBiomolecules
January 2025
National Research Center "Kurchatov Institute", 123182 Moscow, Russia.
The methylotrophic yeast belongs to the group of homothallic fungi that are able to spontaneously change their mating type by inversion of chromosomal DNA in the MAT locus region. As a result, natural and genetically engineered cultures of these yeasts typically contain a mixture of sexually dimorphic cells that are prone to self-diploidisation and spore formation accompanied by genetic rearrangements. These characteristics pose a significant challenge to the development of genetically stable producers for industrial use.
View Article and Find Full Text PDFMuscle Nerve
January 2025
International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada.
Introduction/aims: Upper limb paralysis is arguably the most limiting consequence of cervical spinal cord injury (cSCI). There is limited knowledge regarding the early structural changes of muscles implicated in grasp/pinch function and upper extremity nerve transfer surgeries. We evaluated: (1) muscle size and echo intensity (EI) in subacute cSCI (2-6 months) and (2) the influence of lower motor neuron (LMN) damage on these ultrasound parameters.
View Article and Find Full Text PDFNeurorehabil Neural Repair
January 2025
Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD, USA.
Background: In humans, most spontaneous recovery from motor impairment after stroke occurs in the first 3 months. Studies in animal models show higher responsiveness to training over a similar time-period. Both phenomena are often attributed to a milieu of heightened plasticity, which may share some mechanistic overlap with plasticity associated with normal motor learning.
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