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| http://dx.doi.org/10.1016/j.jaccas.2020.09.012 | DOI Listing |
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Identifying and targeting key driver genes for collagen production within the 11q13/14 breast cancer amplicon.
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Fox Chase Cancer Center, Philadelphia, PA, United States.
Breast cancers of the IntClust-2 type, characterized by amplification of a small portion of chromosome 11, have a median survival of only five years. Several cancer-relevant genes occupy this portion of chromosome 11, and it is thought that overexpression of a combination of driver genes in this region is responsible for the poor outcome of women in this group. In this study we used a gene editing method to knock out, one by one, each of 198 genes that are located within the amplified region of chromosome 11 and determined how much each of these genes contributed to the survival of breast cancer cells.
View Article and Find Full Text PDFManaging pre and postpartum mental health issues of refugee women from fragile and conflict-affected countries: A systematic review.
Public Health Pract (Oxf)
June 2025
Evidence Synthesis Ireland and Cochrane Ireland, University of Galway, Galway, Ireland.
Objective: Refugee or immigrant women residing in conflict prone countries portray elevated mental health related vulnerabilities during their peripartum periods and require effective interventions for improved maternal and child well-being. The objective of this systematic review is to generate evidence on effective interventions for managing peripartum mental health issues among refugee women from conflicted settings.
Study Design: Systematic review.
Barriers and drivers to exclusive breastfeeding in Kyrgyzstan: a qualitative study with mothers and health workers.
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Behavioural and Cultural Insights Unit, WHO Regional Office for Europe, Copenhagen, Denmark.
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View Article and Find Full Text PDFEvaluation of a mentorship matchmaking event at an academic research institution to reinforce the scientific workforce pathway for underrepresented minority groups.
BMC Med Educ
January 2025
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Background: Mentorship and research experiences are crucial for STEMM career entry and advancement. However, systemic barriers have excluded people from historically underrepresented groups.
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Congenital colour vision deficiency in healthcare professionals: a scoping review protocol of the impact on clinical practice and patient safety.
BMJ Open
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Lancaster Medical School, Lancaster University, Lancaster, UK.
Introduction: Congenital colour vision deficiency (CVD), known as colour blindness, is a common visual problem affecting around 1 in 12 men and 1 in 200 women. It is known that people who have red-green CVD, the most common phenotype, can have difficulty differentiating colours and this can impact the ability to perform clinical tasks related to patient care. The objective of this scoping review is to understand the extent and type of evidence and the impact on clinical practice and patient safety arising from congenital CVD in healthcare professionals.
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