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Exploring B-cell epitope conservation and antigenicity shift in current COVID-19 variants: Analyzing spike-antibody interactions for therapeutic uses.
Biochem Biophys Res Commun
December 2024
Amity Institute of Biotechnology, Amity University, Kolkata, India. Electronic address:
SARS-CoV-2, responsible for the global COVID-19 pandemic, has undergone significant genetic changes, leading to various variants impacting transmissibility, severity, and vaccine efficacy. The methodology involved evaluating SARS-CoV-2 variants designated by WHO as Variants of Interest (VOIs) and Variants Under Monitoring (VUMs). Several noteworthy mutations including G446S, K417N, T478K, E484A, N501Y, and Y505H exhibit a strong pattern of convergent evolution across all these variants, particularly at antigenic sites within the spike protein.
View Article and Find Full Text PDFCharacterization of the viral genome of Omicron variants of SARS-CoV-2 circulating in Tripura, a remote frontier state in Northeastern India.
Mol Biol Rep
October 2024
Medical Research Scientist, Viral Research & Diagnostic Laboratory, Agartala Government Medical College & GBP Hospital, Agartala, India.
Introduction: From 2020, with advent of COVID-19 pandemic, Tripura has experienced SARS-CoV-2 viral evolution in accordance with other parts of India. Since January 2022, the Omicron variant of SARS-CoV-2 virus became the predominant lineage circulating in India and neighboring countries. This study characterizes the viral genome of the omicron variant circulating in the state since its inception to June, 2023.
View Article and Find Full Text PDFSewage surveillance of SARS-CoV-2 in Tokyo (May 2020-June 2022): method using high-throughput, fully-automated platform.
Virusdisease
September 2024
Department of Microbiology, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-Cho, Shinjuku-Ku, Tokyo, 169-0073 Japan.
Article Synopsis
- SARS-CoV-2, the virus responsible for COVID-19, can be found in patients' saliva, sputum, and feces, leading to the detection of its RNA in sewage as a way to monitor the spread of the virus.
- A study conducted in Tokyo from May 2020 to June 2022 utilized an automated genetic testing method to monitor two wastewater treatment plants for SARS-CoV-2 RNA.
- The results showed that this automated platform is effective for detecting SARS-CoV-2 RNA and identifying specific spike gene mutations, which correspond to the current status of the pandemic.
Molecular Characterization and Genomic Surveillance of SARS-CoV-2 Lineages in Central India.
Viruses
October 2024
ICMR-National Institute of Research in Tribal Health, Jabalpur 482003, Madhya Pradesh, India.
Since the first reported case of COVID-19 in December 2019, several SARS-CoV-2 variants have evolved, and some of them have shown higher transmissibility, becoming the prevalent strains. Genomic epidemiological investigations into strains from different time points, including the early stages of the pandemic, are very crucial for understanding the evolution and transmission patterns. Using whole-genome sequences, our study describes the early landscape of SARS-CoV-2 variants in central India retrospectively (including the first known occurrence of SARS-CoV-2 in Madhya Pradesh).
View Article and Find Full Text PDFBackground: The widespread increase in multiple variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) since 2020 is causing significant health concerns worldwide. While whole-genome sequencing (WGS) has played a leading role in surveillance programs, many local laboratories lack the expertise and resources. Thus, we aimed to investigate the circulating SARS-CoV-2 variants and evaluate the performance of multiplexed real-time reverse transcription-PCR (RT-PCR) for screening and monitoring the emergence of new SARS-CoV-2 variants in Bangladesh.
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