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Sedation Practices in Mechanically Ventilated Neurocritical Care Patients from 19 Countries: An International Cohort Study.
Neurocrit Care
January 2025
Division of Neuroscience Critical Care, Departments of Neurology, Neurosurgery, and Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Our objective was to characterize the impact of common initial sedation practices on invasive mechanical ventilation (IMV) duration and in-hospital outcomes in patients with acute brain injury (ABI) and to elucidate variations in practices between high-income and middle-income countries.
Methods: This was a post hoc analysis of a prospective observational data registry of neurocritically ill patients requiring IMV. The setting included 73 intensive care units (ICUs) in 18 countries, with a total of 1,450 patients with ABI requiring IMV.
Influences of different sedatives on gastric antrum contraction in patients with acute brain injury.
Front Neurol
December 2024
Neurosurgery ICU, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Patients with acute brain injury (ABI) often exhibit gastrointestinal motility disorder and the administration of sedatives may exacerbate the gastrointestinal dysfunction. This study aims to evaluate the influences of different sedatives on gastric antrum contraction in patients with acute brain injury (ABI).
Methods: A prospective observational study was performed in 37 adult ICU patients with ABI, and 18 adult healthy volunteers were recruited as normal controls.
Effect of Co-Administration of Midazolam and Dexmedetomidine on Haemodynamics and Stress Response in Elderly Patients with Non-Small Cell Lung Cancer.
J Invest Surg
December 2025
Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Objective: This study aimed to evaluate the effect of co-administration of midazolam and dexmedetomidine on hemodynamics and stress response in elderly patients with non-small cell lung cancer (NSCLC).
Methods: In this prospective, randomized controlled trial, 154 elderly NSCLC patients scheduled for lobectomy in our oncology department from January 2019 to December 2021 were recruited. Patients were randomized 1:1 to receive either dexmedetomidine (control group) or dexmedetomidine plus midazolam (study group) for anesthesia during lobectomy the random number table method, with 77 patients in each group.
Tandospirone prevents anesthetic-induced respiratory depression through 5-HT receptor activation in rats.
Sci Rep
January 2025
Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Taiping Road 27, Beijing, 100850, China.
Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have suggested that tandospirone may ameliorate respiratory depression without affecting the sedative effects of anesthetics.
View Article and Find Full Text PDFPre-procedure preparation, monitoring, premedication and sedation practices of bronchoscopists in Türkiye.
Tuberk Toraks
December 2024
Clinic of Anesthesiology and Reanimation, Samsun Education and Research Hospital, Samsun, Türkiye.
Introduction: Sedation is often required during flexible fiberoptic bronchoscopy (FFB) to ensure patient comfort and the success of the procedure. The choice of sedative agents may differ between anesthesiologists and pulmonologists. This pilot study aimed to investigate the current pre-procedure preparation, monitoring, premedication and sedation practices for FFB in Türkiye, focusing on the preferences and practices of pulmonologists.
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