Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria.
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| http://dx.doi.org/10.1016/j.cub.2021.06.014 | DOI Listing |
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Practical considerations in the establishment of psychedelic research programs.
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Rationale: There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing psychedelic research programs.
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Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Harvey Jules Karten passed away on July 15, 2024. With his passing, the world lost a remarkable and energetic man who had made major contributions to neuroscience, in particular, resetting our understanding of the evolution of the forebrain and the evolution of intelligence. He left behind a legion of loyal colleagues with whom he had collaborated and shared ideas, students he had inspired and trained, and non-neuroscientist friends he had made in the passionate pursuit of his hobbies-sailing, skiing, and hiking.
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Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration process, by which transient changes in activity driven by plasticity in the early-learning area are accumulated into persistent synaptic changes at the late-learning site.
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