Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592325 | PMC |
| http://dx.doi.org/10.4269/ajtmh.21-0564b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification and Evaluation of Natural Compounds as Potential Inhibitors of NS2B-NS3 Zika Virus Protease: A Computational Approach.
Mol Biotechnol
December 2024
Unit of Scientific Research, Applied College, Qassim University, Buraydah, 52571, Saudi Arabia.
The Zika virus (ZIKV), an arbovirus within the Flavivirus genus, is associated with severe neurological complications, including Guillain-Barré syndrome in affected individuals and microcephaly in infants born to infected mothers. With no approved vaccines or antiviral treatments available, there is an urgent need for effective therapeutic options. This study aimed to identify new natural compounds with inhibitory potential against the NS2B-NS3 protease (PDB ID: 5LC0), an essential enzyme in viral replication.
View Article and Find Full Text PDFZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin-mediated degradation and facilitate viral replication.
Front Cell Infect Microbiol
December 2024
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
Introduction: Viral infection usually stimulates a variety of host cell factors to modulate the life cycle of the virus. PIM1, a serine/threonine protein kinase widely involved in cell proliferation, survival, differentiation and apoptosis, was recently reported to be upregulated by Zika virus (ZIKV) infection. However, how ZIKV-PIM1 interactions affect the viral life cycle are not fully understood.
View Article and Find Full Text PDFA novel pan-epitope based nanovaccine self-assembled with CpG enhances immune responses against flavivirus.
J Nanobiotechnology
November 2024
College of Basic Medicine, Army Medical University, Gaotanyan str. 30, Chongqing, 400038, China.
Article Synopsis
- Flavivirus infections are widespread and pose significant public health risks, necessitating the urgent development of a safe and effective vaccine, with the self-assembled pan-epitope vaccine being a promising approach.* -
- The study created a nanovaccine called TBT-CpG NaVs, which was found to be stable and effectively taken up by immune cells, enhancing their ability to present antigens and trigger an immune response.* -
- In tests, TBT-CpG NaVs increased specific antibody levels and showed protective benefits against Dengue and Zika viruses, with a good safety profile and no detected organ damage in vaccinated mice, indicating its potential for future vaccine development.*
Development of an Eco-Friendly Nanogel Incorporating Essential Oil as a Larvicidal Agent Against .
Pharmaceutics
October 2024
Laboratory of Chemistry of Natural Products, Department of Chemistry, Federal University of Maranhão (UFMA), São Luís 65080-805, Brazil.
Background/objectives: Arboviruses, transmitted by mosquitoes like , pose significant public health challenges globally, particularly in tropical regions. The rapid spread and adaptation of viruses such as Dengue, Zika, and Chikungunya have emphasized the need for innovative control methods. Essential oils from plants, such as (Gardner) Sch.
View Article and Find Full Text PDFRole of RNA G-Quadruplexes in the Japanese Encephalitis Virus Genome and Their Recognition as Prospective Antiviral Targets.
ACS Infect Dis
October 2024
Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol 453552, India.
Article Synopsis
- The study highlights the emerging interest in G-quadruplexes (GQs) beyond cancer and neurodegenerative diseases, focusing on their roles in viral genomes, particularly in human pathogens like the Japanese encephalitis virus (JEV).
- Researchers identified eight potential GQ-forming motifs in JEV that are important for the virus's replication and assembly and confirmed their stability and ability to form GQs through various assays.
- The compound BRACO-19 was found to bind effectively to these GQs, exhibiting antiviral properties by reducing viral replication and protein expression, underscoring the potential of GQs as targets for antiviral strategies against JEV.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!