Background: Directly observed therapy programs for monitoring tuberculosis (TB) treatment in Thailand are unsustainable, especially during the COVID-19 pandemic. The current video-observed therapy (VOT) system, the Thai VOT (TH VOT), was developed to replace the directly observed therapy program.
Objective: This study aimed to describe the VOT system design and identify the potential for system improvements.
Methods: This pilot study was conducted in Na Yong district, a small district in Trang province, south of Thailand. The TH VOT system consists of a smartphone app for patients, a secured web-based platform for staff, items used, and standard operating procedures. There were three groups of users: observers who were TB staff, healthy volunteers as simulated patients, and patients with active TB. All participants were trained to follow the standard operating procedures. After 2-week usage, VOT session records were analyzed to measure the compliance of the patients and observers. The User Experience Questionnaire was used to lead the participant users to focus on 6 standard dimensions of usability, and was supplemented with an in-depth interview to identify potential system improvements from users' experience.
Results: Only 2 of 16 patients with currently active TB had a usable smartphone. Sixty of 70 drug-taking sessions among 2 patients and 3 simulated patients in 2 weeks were recorded and uploaded. Only 37 sessions were inspected by the observers within 24 hours. All participants needed a proper notification system. An audit system was also requested.
Conclusions: Before upscaling, the cost of smartphone lending, audit management, and notification systems should be elucidated.
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http://dx.doi.org/10.2196/29463 | DOI Listing |
World J Microbiol Biotechnol
January 2025
Institute of Climate Adaptation and Marine Biotechnology (ICAMB), Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, 21030, Malaysia.
Vibrio parahaemolyticus poses a notable threat to marine ecosystems and can cause infections and disease outbreaks in seafood species, which can affect humans upon consumption. The global impacts of such infections and outbreaks on human and animal health led to a growing number of studies from various countries discussing the prevention, control, treatment, and overall implications of V. parahaemolyticus.
View Article and Find Full Text PDFNeural Netw
January 2025
Ningbo Institute of Intelligent Equipment Technology Company Ltd., Ningbo, 315200, China; Department of Automation, University of Science and Technology of China, Hefei, 230027, China.
Discriminative correlation filters with temporal regularization have recently attracted much attention in mobile video tracking, due to the challenges of target occlusion and background interference. However, rigidly penalizing the variability of templates between adjacent frames makes trackers lazy for target evolution, leading to inaccurate responses or even tracking failure when deformation occurs. In this paper, we address the problem of instant template learning when the target undergoes drastic variations in appearance and aspect ratio.
View Article and Find Full Text PDFBMJ Glob Health
October 2024
McGill International Tuberculosis Centre, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
Background: Digital adherence technologies (DATs) may provide a patient-centred approach to supporting tuberculosis (TB) medication adherence and improving treatment outcomes. We synthesised evidence addressing costs and cost-effectiveness of DATs to support TB treatment.
Methods: A systematic review (PROSPERO-CRD42022313531) identified relevant literature from January 2000 to April 2023 in MEDLINE, Embase, CENTRAL, CINAHL, Web of Science along with preprints from medRxiv, Europe PMC and ClinicalTrials.
PLoS One
October 2024
The Graduate Center, City University of New York, New York, New York, United States of America.
Many studies have shown that input in more than one language influences children's phonemic development. In this study, we examined the neural processes supporting perception of Voice Onset Time (VOT) in bilingual Italian-German children and their monolingual German peers. While German contrasts short-lag and long-lag, Italian contrasts short-lag and voicing lead.
View Article and Find Full Text PDFIndian J Tuberc
October 2024
Department of Community Medicine, MVPS's Dr. Vasantrao Pawar Medical College, Vasantdada Nagar, Adgaon, Nashik, 422003, India. Electronic address:
Introduction: Poor adherence to anti-tuberculosis medication is a major barrier to its global control. Patient adherence to the standard anti-TB therapy (ATT) in developing countries has been estimated to be as low as 40%. Multiple factors influencing adherence to treatment are: Economic and structural factors such as homelessness, unemployment and poverty; patient related factors like ethnicity, gender, age, knowledge about TB, cultural belief systems, mental state etc.
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