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Transient apical breakdown associated with clear aligner therapy: a case report.
Br Dent J
January 2025
Reader in Orthodontics and Honorary Consultant in Orthodontics, Centre for Oral Bioengineering, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, Whitechapel, London, E1 2AD, UK.
Transient apical breakdown (TAB) is widely reported in response to trauma, yet its occurrence due to orthodontic forces, particularly in aligner therapy, is less documented within current literature. TAB can easily be misdiagnosed as pulp necrosis, potentially leading to unnecessary and irreversible endodontic procedures. This case report describes an instance of TAB following the initiation of aligner treatment, where the affected tooth initially presented with signs suggesting pulp necrosis but regained normal coloration and pulpal response after six months of active monitoring.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic has significantly strained healthcare systems globally, leading to an overwhelming influx of patients and exacerbating resource limitations. Concurrently, an "infodemic" of misinformation, particularly prevalent in women's health, has emerged. This challenge has been pivotal for healthcare providers, especially gynecologists and obstetricians, in managing pregnant women's health.
View Article and Find Full Text PDF3D bioprinting approaches for enhancing stem cell-based neural tissue regeneration.
Acta Biomater
January 2025
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 123 Bevier Road, Piscataway, NJ 08854, USA. Electronic address:
Three-dimensional (3D) bioprinting holds immense promise for advancing stem cell research and developing novel therapeutic strategies in the field of neural tissue engineering and disease modeling. This paper critically analyzes recent breakthroughs in 3D bioprinting, specifically focusing on its application in these areas. We comprehensively explore the advantages and limitations of various 3D printing methods, the selection and formulation of bioink materials tailored for neural stem cells, and the incorporation of nanomaterials with dual functionality, enhancing the bioprinting process and promoting neurogenesis pathways.
View Article and Find Full Text PDFN-methyladenosine RNA methylation regulates microplastics-induced cell senescence in the rainbow trout liver.
Sci Total Environ
January 2025
School of Bioengineering and Technology, Tianshui Normal University, Gansu Province, PR China. Electronic address:
Microplastics are prevalent in aquatic ecosystems, impacting various forms of aquatic life, including fish. In this study, Rainbow trout (Oncorhynchus mykiss) were exposed to two concentrations of microplastics (0 and 500 μg/L) over a 14-day period, during which a comprehensive analysis was conducted to assess the liver accumulation of microplastics and their effects on oxidative stress, the liver response, and transcriptomics. Our findings indicated that microplastics significantly accumulated in the liver and activated the antioxidant system in fish by enhancing the activity of antioxidant enzymes.
View Article and Find Full Text PDFQuantitative determination of leptin hormone using gold nanoparticle-based lateral flow assay.
Mikrochim Acta
January 2025
Science and Technology Research and Application Center (BITAM), Necmettin Erbakan University, Konya, Türkiye.
A lateral flow assay (LFA) has been developed that can be used in point-of-care (PoC) use for the sensitive determination of leptin hormone. The limit of detection value was 0.158 ng/mL and the limit of quantification value was 0.
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