In this narrative essay, the author, a family physician, remembers his encounters with patients at his 2008 retirement tea following 34 years in practice. The physician and the patients explored their experiences working together and expressed their gratitude to each other. The author looks back at how these long-standing relationships led to better care and better health.
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http://dx.doi.org/10.3122/jabfm.2021.04.200453 | DOI Listing |
Bioact Mater
March 2025
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong, 264005, China.
Despite significant advances in targeted therapies and immunotherapies, non-small cell lung cancer (NSCLC) continues to present a global health challenge, with a modest five-year survival rate of 28 %, largely due to the emergence of treatment-resistant and metastatic tumors. In response, we synthesized a novel bioactive compound, ethyl 6-chlorocoumarin-3-carboxylyl L-theanine (TClC), which significantly inhibited NSCLC growth, epithelial mesenchymal transition (EMT), migration, and invasion and tumor growth and metastasis without inducing toxicity. TClC disrupts autocrine loops that promote tumor progression, particularly in stem-like CD133-positive NSCLC (CD133+ LC) cells, which are pivotal in tumor metastasis.
View Article and Find Full Text PDFExplore (NY)
January 2025
Institute of Neuroscience and Department of Human Physiology, University of Oregon, Eugene, OR 97403, USA. Electronic address:
This Reflection piece offers eight insights that have been gleaned from enlightened masters related to the nature of consciousness, awareness and experience. These insights are elucidated in ways that can help in the evaluation of the usefulness of our values and beliefs, and how these dictate the way we respond to our life experiences. In this way the essay points to the importance of cultivating and refining one's own awareness because it is the level of our awareness that controls the flow of creativity and experience, both into and out of our lives.
View Article and Find Full Text PDFJ Nutr Health Aging
January 2025
Department of Public Health, University of Helsinki, P.O. Box 20, (Tukholmankatu 8 2B), 00014 Helsinki, Finland.
Objectives: Socioeconomic differences in fruit and vegetable (F&V) consumption are recognized, but little is known about how these differences develop when moving from mid-life to older adulthood. We investigated the longitudinal changes in socioeconomic differences in F&V consumption in an ageing Finnish cohort, using occupational class as a measure of socioeconomic position. Additionally, we examined whether socioeconomic differences in F&V consumption changed over retirement transition.
View Article and Find Full Text PDFPak J Med Sci
January 2024
Muhammad Tariq Baqai. MBBS, FRCP. Professor (Retired), Department of Medicine, HBS Medical and Dental College, Islamabad, Pakistan.
Treatment of Gastro-Esophageal Reflux Disease (GERD) is becoming a challenge. Proton pump inhibitors (PPIs) are commonly prescribed but have many risks, particularly in long-term use. In an earlier pilot study, we have reported benefits of short-term practice of a new life-style, two meals a day with only liquids in between, for management of GERD.
View Article and Find Full Text PDFPrev Med
February 2024
Department of Public Health, PO BOX 20 (Tukholmankatu 8 B), 00014 University of Helsinki, Finland. Electronic address:
Background: We examined individual and dual trajectories of insomnia symptoms and body mass index (BMI) before and after retirement, and their associations with changes in subjective cognitive functioning after retirement.
Methods: We used the Helsinki Health Study's (n = 2360, 79% women, aged 40-60 at baseline, Finland) repeated surveys to identify the developmental patterns of insomnia symptoms and BMI (2000-2017) and changes in subjective cognitive functioning (2017-2022). We analysed the data using latent group-based dual trajectory modelling and logistic regression analysis.
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